Hypovitaminosis D and metabolic syndrome

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© 2013 Elsevier España, S.L.U. All rights reserved. Metabolic syndrome and hypovitaminosis D are 2 diseases with high prevalence that share several risk factors, while epidemiological evidence shows they are associated. Although the mechanisms involved in this association are not well established, hypovitaminosis D is associated with insulin resistance, decreased insulin secretion and activation of the renin-angiotensin system, mechanisms involved in the pathophysiology of metabolic syndrome. However, the apparent ineffectiveness of vitamin D supplementation on metabolic syndrome components, as well as the limited information about the effect of improving metabolic syndrome components on vitamin D concentrations, does not clarify the direction and the mechanisms involved in the causal relationship between these 2 pathologies. Overall, because of the high prevalence and the epidemiological association between both diseases, hypovitaminosis D could be considered a component of the metabolic syndrome.
Original languageEnglish
Pages (from-to)542-547
JournalMedicina Clinica
Issue number12
Publication statusPublished - 1 Jan 2014


  • Diabetes
  • Metabolic syndrome
  • Vitamin D


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