TY - JOUR
T1 - Hypothalamic-pituitary-adrenal axis-related genes and cognition in major mood disorders and schizophrenia
T2 - a systematic review
AU - Ferrer, Alex
AU - Labad, Javier
AU - Salvat-Pujol, Neus
AU - Monreal, José A.
AU - Urretavizcaya, Mikel
AU - Crespo, José M.
AU - Menchón, José M.
AU - Palao, Diego
AU - Soria, Virginia
N1 - Funding Information:
This study was supported in part by grants from the Carlos III Health Institute through the Spanish Ministry of Economy and Competitiveness ( PI10/01753 and PI15/00662 ), co-funded by the European Regional Development Fund (ERDF) “A way to build Europe”, CIBERSAM , and the Catalan Agency for the Management of University and Research Grants ( AGAUR 2017 SGR 1247 ). We also thank CERCA Programme/ Generalitat de Catalunya for institutional support. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Dr. Labad received an Intensification of the Research Activity Grant by the Generalitat de Catalunya ( SLT006/17/00012 ).
PY - 2020/7/13
Y1 - 2020/7/13
N2 - Hypothalamic-pituitary-adrenal (HPA) axis dysregulation and cognitive deficits are two well-characterized endophenotypes present in different serious mental illnesses (SMIs), including major depressive disorder, bipolar disorder and schizophrenia. Our aim was to study the influence of genetic and epigenetic variations in HPA axis-related genes on cognitive performance in clinical samples, including patients with major mood disorders and schizophrenia. A systematic search was performed using PubMed (Medline), PsycINFO and Scopus databases. The systematic review identified 12 studies dealing with HPA-related genes and cognition in samples including patients with SMIs, focusing on single nucleotide polymorphism (SNP) variants, while no studies analysing epigenetic variations were found. The results suggest different and specific effects on the cognitive performance of SNP variants in the HPA axis-related genes studied, as well as interactions with traumatic experiences. There was high heterogeneity in the studied samples, genes analysed, and cognitive tasks evaluated. The relationship between HPA-related genes and cognition in SMIs is still largely unknown, and further studies including larger samples and epigenetic variations are needed.
AB - Hypothalamic-pituitary-adrenal (HPA) axis dysregulation and cognitive deficits are two well-characterized endophenotypes present in different serious mental illnesses (SMIs), including major depressive disorder, bipolar disorder and schizophrenia. Our aim was to study the influence of genetic and epigenetic variations in HPA axis-related genes on cognitive performance in clinical samples, including patients with major mood disorders and schizophrenia. A systematic search was performed using PubMed (Medline), PsycINFO and Scopus databases. The systematic review identified 12 studies dealing with HPA-related genes and cognition in samples including patients with SMIs, focusing on single nucleotide polymorphism (SNP) variants, while no studies analysing epigenetic variations were found. The results suggest different and specific effects on the cognitive performance of SNP variants in the HPA axis-related genes studied, as well as interactions with traumatic experiences. There was high heterogeneity in the studied samples, genes analysed, and cognitive tasks evaluated. The relationship between HPA-related genes and cognition in SMIs is still largely unknown, and further studies including larger samples and epigenetic variations are needed.
KW - Bipolar disorder
KW - Cognition
KW - Genetics
KW - Hypothalamic-pituitary-adrenal axis
KW - Major depressive disorder
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=85082547686&partnerID=8YFLogxK
U2 - 10.1016/j.pnpbp.2020.109929
DO - 10.1016/j.pnpbp.2020.109929
M3 - Artículo de revisión
C2 - 32197928
AN - SCOPUS:85082547686
VL - 101
M1 - 109929
ER -
