Hypertriglyceridemic waist in type 1 diabetes patients: Prevalence and related factors

Mercè Fernández-Miró, Juan J. Chillarón, Mercè Albareda, Sara Fontserè, Cristina Colom, Lluís Vila, Juan Pedro-Botet, Juana A.Flores Le-Roux, C. Colom, M. Fernández, N. Ascoeta, D. Benaiges, M. J. Carrera, J. J. Chillarón, E. Climent, J. A.F. Le-Roux, A. Goday, G. Llauradó, L. Mañé, A. MásJ. Pedro-Botet, J. Puig, M. Renard, E. Sagarra, M. Albareda, L. Vila, M. Prados, J. Ripollés

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3 Citations (Scopus)

Abstract

© 2016-2017 Edizioni Minerva Medica. Background: The hypertriglyceridemic waist has been linked to a higher number of cardiovascular risk factors and a greater probability of developing diabetes and cardiovascular disease. Around 50% of individuals with type 1 diabetes (T1D) are overweight or obese and triglyceridemia is associated with the onset of micro-and macrovascular complications. Methods: Across-sectional study was conducted in men with T1Dto assess the association between the prevalence of hypertriglyceridemic waist and cardiovascular risk factors and hypogonadism. Triglyceride levels + abdominal circumference taken together were stratified into quartiles to identify the hypertriglyceridemic waist phenotype. Results: One hundred and eighty-one male patients were included. An increased prevalence of hypogonadism and hypertension in parallel to increased triglyceride + waist circumference quartile was observed. Patients in the highest quartile had higher insulin resistance measured by estimated glucose disposal rate (eGDR 7.8±2.1 mg/kg-1.min-1 in 1st quartile vs. 5.8±1.8 mg/kg-1.min-1 in 4th quartile, P=0.000), insulin requirements, hip circumference, percentage of fat mass, glycosilated hemoglobin and total and LDL cholesterol as well as lower levels of total testosterone (27.24±9.3 nmol/L in 1st quartile vs. 17.4±8 nmol/L in 4th quartile, P=0.000) and HDL cholesterol. An inverse relationship was found between triglycerides + waist circumference and total testosterone levels (R=-0.367, P<0.0001). Conclusions: The hypertriglyceridemic waist in men with T1D is associated with an atherogenic lipid profile, hypertension, worse metabolic diabetes control, increased insulin resistance and a higher prevalence of hypogonadism.
Original languageEnglish
Pages (from-to)1-7
JournalMinerva Endocrinologica
Volume42
Issue number1
DOIs
Publication statusPublished - 1 Mar 2017

Keywords

  • Diabetes mellitus, type 1
  • Hypertriglyceridemic waist
  • Metabolic syndrome X

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