Hyperthyroidism in Down síndrome

Cristina Claret-Torrents; Albert Goday-Arno; Mariaina Cerdà-Esteve; Juana Flores-Le Roux; Juan José Chillarón-Jordan; Juan Francisco Cano-Pérez

Hyperthyroidism in Down síndrome

Cristina Claret-Torrents, Albert Goday-Arno, Mariaina Cerdà-Esteve, Juana Flores-Le Roux, Juan José Chillarón-Jordan, Juan Francisco Cano-Pérez

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

Abstract

Thyroid conditions, particularly hypothyroidism, are common in people with Down syndrome (DS). Hyperthyroidism is also found at a higher-than-average rate in patients with DS, although only isolated case reports and short series had been published up until now. We recently published the longest series so far examining the relationship between hyperthyroidism and DS. A systematic review of the 1,856 patients seen at Fundació Catalana Síndrome de Down (FCSD) from 1991 to 2006 was undertaken, and 12 cases of hyperthyroidism were diagnosed. The etiological cause was found to be Graves disease in all cases. After initial treatment with antithyroid drugs, all patients required definitive treatment with radioactive iodine I-131. Annual biochemical screening for early diagnosis is less effective than it is for hypothyroidism. Hyperthyroidism may influence growth and development in children with DS; treatment can reverse its impact.

Original language	English
Pages (from-to)	2-8
Journal	SD Revista Medica Internacional sobre el Sindrome de Down
Volume	13
Issue number	1
Publication status	Published - 1 Jan 2009

Keywords

Down syndrome
Graves disease
Growth
Hyperthyroidism
Thyroid gland

Cite this

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abstract = "Thyroid conditions, particularly hypothyroidism, are common in people with Down syndrome (DS). Hyperthyroidism is also found at a higher-than-average rate in patients with DS, although only isolated case reports and short series had been published up until now. We recently published the longest series so far examining the relationship between hyperthyroidism and DS. A systematic review of the 1,856 patients seen at Fundaci{\'o} Catalana S{\'i}ndrome de Down (FCSD) from 1991 to 2006 was undertaken, and 12 cases of hyperthyroidism were diagnosed. The etiological cause was found to be Graves disease in all cases. After initial treatment with antithyroid drugs, all patients required definitive treatment with radioactive iodine I-131. Annual biochemical screening for early diagnosis is less effective than it is for hypothyroidism. Hyperthyroidism may influence growth and development in children with DS; treatment can reverse its impact.",

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AU - Claret-Torrents, Cristina

AU - Goday-Arno, Albert

AU - Cerdà-Esteve, Mariaina

AU - Flores-Le Roux, Juana

AU - Chillarón-Jordan, Juan José

AU - Cano-Pérez, Juan Francisco

PY - 2009/1/1

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N2 - Thyroid conditions, particularly hypothyroidism, are common in people with Down syndrome (DS). Hyperthyroidism is also found at a higher-than-average rate in patients with DS, although only isolated case reports and short series had been published up until now. We recently published the longest series so far examining the relationship between hyperthyroidism and DS. A systematic review of the 1,856 patients seen at Fundació Catalana Síndrome de Down (FCSD) from 1991 to 2006 was undertaken, and 12 cases of hyperthyroidism were diagnosed. The etiological cause was found to be Graves disease in all cases. After initial treatment with antithyroid drugs, all patients required definitive treatment with radioactive iodine I-131. Annual biochemical screening for early diagnosis is less effective than it is for hypothyroidism. Hyperthyroidism may influence growth and development in children with DS; treatment can reverse its impact.

AB - Thyroid conditions, particularly hypothyroidism, are common in people with Down syndrome (DS). Hyperthyroidism is also found at a higher-than-average rate in patients with DS, although only isolated case reports and short series had been published up until now. We recently published the longest series so far examining the relationship between hyperthyroidism and DS. A systematic review of the 1,856 patients seen at Fundació Catalana Síndrome de Down (FCSD) from 1991 to 2006 was undertaken, and 12 cases of hyperthyroidism were diagnosed. The etiological cause was found to be Graves disease in all cases. After initial treatment with antithyroid drugs, all patients required definitive treatment with radioactive iodine I-131. Annual biochemical screening for early diagnosis is less effective than it is for hypothyroidism. Hyperthyroidism may influence growth and development in children with DS; treatment can reverse its impact.

KW - Down syndrome

KW - Graves disease

KW - Growth

KW - Hyperthyroidism

KW - Thyroid gland

M3 - Article

SN - 1138-011X

VL - 13

SP - 2

EP - 8

JO - SD. Revista mèdica internacional sobre la Síndrome de Down (Ed. a català)

JF - SD. Revista mèdica internacional sobre la Síndrome de Down (Ed. a català)

IS - 1

ER -

Hyperthyroidism in Down síndrome

Abstract

Keywords

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