Hypersensitivity Pneumonitis Due to Isocyanates: Lung Function, Clinical and Radiological Characteristics

Ane Uranga, Mónica Sánchez-Ortiz, Ferran Morell, Maria Jesus Cruz, Xavier Muñoz

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    The objective of this present study was to describe the clinical-radiological and lung function characteristics of hypersensitivity pneumonitis due to exposure to isocyanates (HPI). Included for study were all those patients diagnosed with HPI (n=5) from 1995-2010. In all cases, chest CT and complete lung function studies were done. The diagnosis was made with positive specific bronchial provocation tests (BPT). A predominance of males and pattern variability in the radiological alterations were observed. The BPT was positive due to a decline in FVC or DLCO in all cases except in one patient in whom the diagnosis was established with clinical criteria. Positive IgG to isocyanates was confirmed in only one patient. The radiological presentation of HPI may be different from the more common HP in our setting and run their course with less clinical affectation on the BPT. © 2012 SEPAR.
    Original languageEnglish
    Pages (from-to)169-172
    JournalArchivos de Bronconeumologia
    Issue number4
    Publication statusPublished - 1 Apr 2013


    • Low molecular weight
    • Occupational exposure
    • Specific bronchial provocation


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