Hypersensitivity Pneumonitis Due to Isocyanates: Lung Function, Clinical and Radiological Characteristics

Ane Uranga; Mónica Sánchez-Ortiz; Ferran Morell; Maria Jesus Cruz; Xavier Muñoz

doi:10.1016/j.arbres.2012.08.004

Hypersensitivity Pneumonitis Due to Isocyanates: Lung Function, Clinical and Radiological Characteristics

Ane Uranga, Mónica Sánchez-Ortiz, Ferran Morell, Maria Jesus Cruz, Xavier Muñoz

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Abstract

The objective of this present study was to describe the clinical-radiological and lung function characteristics of hypersensitivity pneumonitis due to exposure to isocyanates (HPI). Included for study were all those patients diagnosed with HPI (n=5) from 1995-2010. In all cases, chest CT and complete lung function studies were done. The diagnosis was made with positive specific bronchial provocation tests (BPT). A predominance of males and pattern variability in the radiological alterations were observed. The BPT was positive due to a decline in FVC or DLCO in all cases except in one patient in whom the diagnosis was established with clinical criteria. Positive IgG to isocyanates was confirmed in only one patient. The radiological presentation of HPI may be different from the more common HP in our setting and run their course with less clinical affectation on the BPT. © 2012 SEPAR.

Original language	English
Pages (from-to)	169-172
Journal	Archivos de Bronconeumologia
Volume	49
Issue number	4
DOIs	https://doi.org/10.1016/j.arbres.2012.08.004
Publication status	Published - 1 Apr 2013

Keywords

Low molecular weight
Occupational exposure
Specific bronchial provocation

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title = "Hypersensitivity Pneumonitis Due to Isocyanates: Lung Function, Clinical and Radiological Characteristics",

abstract = "The objective of this present study was to describe the clinical-radiological and lung function characteristics of hypersensitivity pneumonitis due to exposure to isocyanates (HPI). Included for study were all those patients diagnosed with HPI (n=5) from 1995-2010. In all cases, chest CT and complete lung function studies were done. The diagnosis was made with positive specific bronchial provocation tests (BPT). A predominance of males and pattern variability in the radiological alterations were observed. The BPT was positive due to a decline in FVC or DLCO in all cases except in one patient in whom the diagnosis was established with clinical criteria. Positive IgG to isocyanates was confirmed in only one patient. The radiological presentation of HPI may be different from the more common HP in our setting and run their course with less clinical affectation on the BPT. {\textcopyright} 2012 SEPAR.",

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T1 - Hypersensitivity Pneumonitis Due to Isocyanates: Lung Function, Clinical and Radiological Characteristics

AU - Uranga, Ane

AU - Sánchez-Ortiz, Mónica

AU - Morell, Ferran

AU - Cruz, Maria Jesus

AU - Muñoz, Xavier

PY - 2013/4/1

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N2 - The objective of this present study was to describe the clinical-radiological and lung function characteristics of hypersensitivity pneumonitis due to exposure to isocyanates (HPI). Included for study were all those patients diagnosed with HPI (n=5) from 1995-2010. In all cases, chest CT and complete lung function studies were done. The diagnosis was made with positive specific bronchial provocation tests (BPT). A predominance of males and pattern variability in the radiological alterations were observed. The BPT was positive due to a decline in FVC or DLCO in all cases except in one patient in whom the diagnosis was established with clinical criteria. Positive IgG to isocyanates was confirmed in only one patient. The radiological presentation of HPI may be different from the more common HP in our setting and run their course with less clinical affectation on the BPT. © 2012 SEPAR.

AB - The objective of this present study was to describe the clinical-radiological and lung function characteristics of hypersensitivity pneumonitis due to exposure to isocyanates (HPI). Included for study were all those patients diagnosed with HPI (n=5) from 1995-2010. In all cases, chest CT and complete lung function studies were done. The diagnosis was made with positive specific bronchial provocation tests (BPT). A predominance of males and pattern variability in the radiological alterations were observed. The BPT was positive due to a decline in FVC or DLCO in all cases except in one patient in whom the diagnosis was established with clinical criteria. Positive IgG to isocyanates was confirmed in only one patient. The radiological presentation of HPI may be different from the more common HP in our setting and run their course with less clinical affectation on the BPT. © 2012 SEPAR.

KW - Low molecular weight

KW - Occupational exposure

KW - Specific bronchial provocation

U2 - 10.1016/j.arbres.2012.08.004

DO - 10.1016/j.arbres.2012.08.004

M3 - Article

VL - 49

SP - 169

EP - 172

IS - 4

ER -

Hypersensitivity Pneumonitis Due to Isocyanates: Lung Function, Clinical and Radiological Characteristics

Abstract

Keywords

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