TY - JOUR
T1 - Hyoscine butylbromide mode of action on bowel motility:
T2 - From pharmacology to clinical practice
AU - Corsetti, Maura
AU - Forestier, Sylvie
AU - Jiménez, Marcel
N1 - © 2022 The Authors. Neurogastroenterology & Motility published by John Wiley & Sons Ltd.
PY - 2023/4
Y1 - 2023/4
N2 - Background: Hyoscine butylbromide (HBB) has been available for use as an antispasmodic since 1951 and is indicated for the treatment of abdominal pain associated with cramps. A previous review in 2007 summarized the evidence on the mode of action of HBB in vitro and in vivo in both animal and human studies. However, since then, novel publications have appeared within the literature and also our knowledge of what represents normal motility in humans has evolved. Purpose: This review is the result of the collaboration between a basic scientist and clinicians with the aim of providing an updated overview of the mechanisms of action of HBB and its clinical efficacy to guide not only use in clinical practice, but also future research.
AB - Background: Hyoscine butylbromide (HBB) has been available for use as an antispasmodic since 1951 and is indicated for the treatment of abdominal pain associated with cramps. A previous review in 2007 summarized the evidence on the mode of action of HBB in vitro and in vivo in both animal and human studies. However, since then, novel publications have appeared within the literature and also our knowledge of what represents normal motility in humans has evolved. Purpose: This review is the result of the collaboration between a basic scientist and clinicians with the aim of providing an updated overview of the mechanisms of action of HBB and its clinical efficacy to guide not only use in clinical practice, but also future research.
KW - Abdominal Pain/drug therapy
KW - Animals
KW - Butylscopolammonium Bromide/pharmacology
KW - Humans
KW - Parasympatholytics/pharmacology
KW - Scopolamine
UR - http://www.scopus.com/inward/record.url?scp=85135949922&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/7dd0b477-8515-3750-9fcc-83ad17fbb9de/
U2 - 10.1111/nmo.14451
DO - 10.1111/nmo.14451
M3 - Review article
C2 - 35972266
AN - SCOPUS:85135949922
SN - 1350-1925
VL - 35
JO - Neurogastroenterology and Motility
JF - Neurogastroenterology and Motility
IS - 4
M1 - e14451
ER -