Hydrophobic gold nanoparticle self-assembly with phosphatidylcholine lipid: Membrane-loaded and janus vesicles

Michael R. Rasch, Emma Rossinyol, Jose L. Hueso, Brian W. Goodfellow, Jordi Arbiol, Brian A. Korgel

    Research output: Contribution to journalArticleResearchpeer-review

    174 Citations (Scopus)

    Abstract

    Hybrids of hydrophobic sub-2-nm-diameter dodecanethiol-coated Au nanoparticles and phosphatidylcholine (PC) lipid vesicles made by extrusion were examined by cryogenic transmission electron microscopy (cryoTEM). The nanoparticles loaded the vesicles as a dense monolayer in the hydrophobic core of the lipid bilayer, without disrupting their structure. Nanoparticle-vesicle hybrids could also be made by a dialysis process, mixing preformed vesicles with detergent-stabilized nanoparticles, but this approach led to vesicles only partially loaded with nanoparticles that segregated into hemispherical domains, forming a Janus vesicle-nanoparticle hybrid structure. © 2010 American Chemical Society.
    Original languageEnglish
    Pages (from-to)3733-3739
    JournalNano Letters
    Volume10
    Issue number9
    DOIs
    Publication statusPublished - 8 Sep 2010

    Keywords

    • cryoTEM
    • detergent dialysis
    • extrusion
    • Gold nanocrystal
    • Janus particle
    • lipid assembly
    • liposomes
    • nanoparticles
    • self-assembly
    • vesicles

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