Hydroamination of alkynes with ammonia: Unforeseen role of the gold(I) catalyst

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Abstract

Putting two and two together: Two key factors were found to account for the efficiency of the gold(I)/ligand catalyst in the hydroamination of alkynes with ammonia. On one hand, the excess nucleophile, NH 3, assists in the proton transfer, and on the other an unforeseen [Au] migration allows a feasible enamine-imine tautomerization. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Original languageEnglish
Pages (from-to)11147-11151
JournalAngewandte Chemie - International Edition
Volume50
Issue number47
DOIs
Publication statusPublished - 18 Nov 2011

Keywords

  • alkynes
  • computational chemistry
  • density functional calculations
  • gold
  • hydroamination

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