Hybrid capture 2 high-risk human papillomavirus test should "grey zone" results justify repeating the test?

Angels Ramirez-Hidalgo, Mercè Musset-Biarnes, Maria Vilamala-Muns, Elisa Laso-Perez, Laia Serrano-Munne, Francesc Alameda-Quitllet

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

To determine the clinical importance of repeating the Hybrid Capture 2 (HC2) high-risk human papillomavirus (HPV) test when the result obtained falls between 2.7 and 0.8 pg/mL, the so-called "grey zone." STUDY DESIGN: Repeat testing was performed on 139 thin-layer liquid-based cytology cervicovaginal samples that were found to fall in the grey zone. The samples represented a variety of cytological diagnoses. The results of both HPV HC2 tests were analyzed related to the cytological diagnosis of both the previous and the follow-up cytological samples. RESULTS: The change of the HPV HC2 result from positive (2.7-1 pg/mL) to negative (< 1 pg/mL) when repeating the test is not related with the diagnosis obtained in the cytological follow-up of the patient. CONCLUSION: The HC2 test should not be repeated when the result falls between 2.7 and 0.8 pg/mL. In these cases the result of the cytology is more relevant and should be used in the clinical assessment of the patient. (Anal Quant Cytopathol Histopathol 2013;35:152-156). © Science Printers and Publishers, Inc.
Original languageEnglish
Pages (from-to)152-156
JournalAnalytical and Quantitative Cytology and Histology
Volume35
Issue number3
Publication statusPublished - 1 Jun 2013

Keywords

  • Cervical smears
  • Cytology
  • HPV DNA tests
  • Human papillomavirus

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