TY - JOUR
T1 - Human Studies on the Biological Actions of IGF-1. Evidence Suggesting that Human Fetal and Postnatal Epiphyseal Cartilage is a Target Tissue for IGF-1 Action
AU - Carrascosa, Antonio
AU - Audí, Laura
PY - 1993/1/1
Y1 - 1993/1/1
N2 - Recent data show that in humans IGF-1 has insulin-like anabolic and growth promoting effects. However, the plasma levels at which IGF-1 exerts these effects differ. IGF-1 plasma levels similar to those in normal children and adults have a growth promoting effect, but higher levels are necessary for IGF-1 to exert insulin-like anabolic effects, and hypoglycemia is a potential risk. Longitudinal bone growth results from the proliferation and differentiation of chondrocytes in epiphyseal cartilage. We present our data from cultured human epiphyseal chondrocytes, which suggest that epiphyseal cartilage may be a target tissue for IGF-1 action during human fetal and postnatal development. © 1993, IEEE. All rights reserved.
AB - Recent data show that in humans IGF-1 has insulin-like anabolic and growth promoting effects. However, the plasma levels at which IGF-1 exerts these effects differ. IGF-1 plasma levels similar to those in normal children and adults have a growth promoting effect, but higher levels are necessary for IGF-1 to exert insulin-like anabolic effects, and hypoglycemia is a potential risk. Longitudinal bone growth results from the proliferation and differentiation of chondrocytes in epiphyseal cartilage. We present our data from cultured human epiphyseal chondrocytes, which suggest that epiphyseal cartilage may be a target tissue for IGF-1 action during human fetal and postnatal development. © 1993, IEEE. All rights reserved.
U2 - 10.1515/JPEM.1993.6.3-4.257
DO - 10.1515/JPEM.1993.6.3-4.257
M3 - Article
VL - 6
SP - 257
EP - 262
JO - Journal of Pediatric Endocrinology and Metabolism
JF - Journal of Pediatric Endocrinology and Metabolism
SN - 0334-018X
IS - 3-4
ER -