Human sperm chromosomes. Long-term effect of cancer treatment

Anna Genescà; M. Rosa Caballín; Rosa Miró; Jordi Benet; Xavier Bonfill; Josep Egozcue

doi:https://doi.org/10.1016/0165-4608(90)90110-V

Human sperm chromosomes. Long-term effect of cancer treatment

Anna Genescà, M. Rosa Caballín, Rosa Miró, Jordi Benet, Xavier Bonfill, Josep Egozcue

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Abstract

The long-term cytogenetic effect of radio- or chemotherapy or both on male germ cells was evaluated by study of the chromosomal abnormalities in spermatozoa of four men treated for cancer 5-18 years earlier. The cytogenetic analysis of 422 sperm metaphases showed no differences in the aneuploidy rate. The incidence of structural chromosome aberrations was 14.0%, however, which is much higher than in controls. Thus, the high incidence of structurally aberrant spermatozoa observed in our long-term study indicates that antitumoral treatments affect stem-cell spermatogonia and that aberrant cells can survive germinal selection and produce abnormal spermatozoa. © 1990.

Original language	English
Pages (from-to)	251-260
Journal	Cancer Genetics and Cytogenetics
Volume	46
DOIs	https://doi.org/10.1016/0165-4608(90)90110-V
Publication status	Published - 1 Jan 1990

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Genescà, A., Caballín, M. R., Miró, R., Benet, J., Bonfill, X., & Egozcue, J. (1990). Human sperm chromosomes. Long-term effect of cancer treatment. Cancer Genetics and Cytogenetics, 46, 251-260. https://doi.org/10.1016/0165-4608(90)90110-V

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