Human sperm chromosome studies in a reciprocal translocation t(2;5)

Cristina Templado, Joaquima Navarro, Jordi Benet, Anna Genescà, M. Mar Pérez, José Egozcue

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28 Citations (Scopus)

Abstract

Sperm chromosome complements have been studied in a man heterozygous for a reciprocal translocation t(2;5)(p11;q15). Human sperm chromosomes were obtained after fertilization of zona-free hamster eggs. A total of 75 human sperm metaphases were analysed. Of the complements studied, 59 (78.6%) resulted from a 2:2 segregation and 16 (21.3%) from a 3:1 segregation, 4:0 segregation was not observed. Our results indicate that at least 36% of sperm complements were unbalanced with respect to the translocation. The frequency of other chromosome anomalies unrelated to the translocation was 16%. © 1988 Springer-Verlag.
Original languageEnglish
Pages (from-to)24-28
JournalHuman Genetics
Volume79
DOIs
Publication statusPublished - 1 May 1988

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