Human papillomavirus and breast cancer: No evidence of association in a spanish set of cases

Maria Vernet-Tomas, Marisa Mena, Laia Alemany, Ignacio Bravo, Silvia De Sanjosé, Pau Nicolau, Alba Bergueiro, Josep Maria Corominas, Sergi Serrano, Ramon Carreras, Belen Lloveras

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)


© 2015, International Institute of Anticancer Research. All rights reserved. Background/Aim: Great controversy exists about the association between Human Papillomavirus (HPV) and breast tumors. The aim of this study was to explore the presence of HPV DNA in a large set of breast cancer cases. Materials and Methods: Techniques used followed the standards for an international retrospective survey of HPV-DNA genotyping, coordinated by our own group and the DDL Laboratories in Rijswijk, the Netherlands. Paraffin-embedded samples were used. SPF-10 broad-spectrum primers were applied, followed by deoxyribonucleic acid enzyme immunoassay and genotyping by reverse-line probe assay. Results: A total of 78 samples were included in the study, 2 of benign conditions and 76 carcinomas, including different histological subtypes. HPV was not present in any of the specimens studied irrespective of histology, hormonal status and stage of disease. Conclusion: Our data do not support the involvement of HPV in breast carcinogenesis as no evidence of its presence was found.
Original languageEnglish
Pages (from-to)851-856
JournalAnticancer Research
Issue number2
Publication statusPublished - 1 Jan 2015


  • Breast cancer
  • Human papillomavirus
  • Polymerase chain reaction


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