Human origin of micronuclei in human × hamster two-cell embryos

Laura Tusell, R. Alvarez, A. Genescà, M. R. Caballín, R. Miró, L. Barrios, J. Egozcue

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

Using fluorescence in situ hybridization techniques with either human or hamster genomic DNA probes, we studied the origin of micronuclei in two-cell hybrid embryos obtained from hamster oocytes and γ-irradiated human spermatozoa. Our study demonstrates that over 99 % of micro nuclei hybridize with human DNA probes and not with hamster DNA, revealing their human origin. Thus, the micronucleus test represents a good method to evaluate genetic damage in human germ cells, since it is simpler and faster than sperm chromosome studies. © 1995 S. Karger AG, Basel.
Original languageEnglish
Pages (from-to)41-44
JournalCytogenetic and Genome Research
Volume70
DOIs
Publication statusPublished - 1 Jan 1995

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