Human immunodeficiency virus infection in pregnant women, transmission and zidovudine therapy

M. T. Rovira; M. T. Antorn; A. Payá; E. Castellanos; A. Mur; R. Carreras

doi:10.1016/S0301-2115(00)00499-1

Human immunodeficiency virus infection in pregnant women, transmission and zidovudine therapy

M. T. Rovira, M. T. Antorn, A. Payá, E. Castellanos, A. Mur, R. Carreras

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Abstract

Objective: To determine the rate of mother to child transmission of HIV infection in women treated with zidovudine (ZDV). Patients and methods: A consecutive series of 52 HIV-positive pregnant women who either received antenatal care or delivered at our institution. Forty-three women were known to be HIV positive before delivery. Forty were treated with ZDV, 36 intravenously. Twelve had no antenatal care and one refused antenatal treatment. All neonates were treated with ZDV. Results: The HIV transmission rate in children born to mothers treated with ZDV was 6.6%. This compares with a transmission rate of 14% before we used ZDV. All three mothers who transmitted infection had low compliance, initiated therapy late in pregnancy or had advanced disease. Conclusion: Our experience supports the idea that ZDV treatment has reduced HIV transmission rate. Copyright © 2001 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	46-49
Journal	European Journal of Obstetrics and Gynecology and Reproductive Biology
Volume	97
Issue number	1
DOIs	https://doi.org/10.1016/S0301-2115(00)00499-1
Publication status	Published - 1 Jan 2001

Keywords

Antiretroviral
Perinatal transmission
Pregnancy
Zidovudine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0301-2115(00)00499-1

Cite this

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title = "Human immunodeficiency virus infection in pregnant women, transmission and zidovudine therapy",

abstract = "Objective: To determine the rate of mother to child transmission of HIV infection in women treated with zidovudine (ZDV). Patients and methods: A consecutive series of 52 HIV-positive pregnant women who either received antenatal care or delivered at our institution. Forty-three women were known to be HIV positive before delivery. Forty were treated with ZDV, 36 intravenously. Twelve had no antenatal care and one refused antenatal treatment. All neonates were treated with ZDV. Results: The HIV transmission rate in children born to mothers treated with ZDV was 6.6%. This compares with a transmission rate of 14% before we used ZDV. All three mothers who transmitted infection had low compliance, initiated therapy late in pregnancy or had advanced disease. Conclusion: Our experience supports the idea that ZDV treatment has reduced HIV transmission rate. Copyright {\textcopyright} 2001 Elsevier Science Ireland Ltd.",

keywords = "Antiretroviral, Perinatal transmission, Pregnancy, Zidovudine",

author = "Rovira, {M. T.} and Antorn, {M. T.} and A. Pay{\'a} and E. Castellanos and A. Mur and R. Carreras",

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doi = "10.1016/S0301-2115(00)00499-1",

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T1 - Human immunodeficiency virus infection in pregnant women, transmission and zidovudine therapy

AU - Rovira, M. T.

AU - Antorn, M. T.

AU - Payá, A.

AU - Castellanos, E.

AU - Mur, A.

AU - Carreras, R.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Objective: To determine the rate of mother to child transmission of HIV infection in women treated with zidovudine (ZDV). Patients and methods: A consecutive series of 52 HIV-positive pregnant women who either received antenatal care or delivered at our institution. Forty-three women were known to be HIV positive before delivery. Forty were treated with ZDV, 36 intravenously. Twelve had no antenatal care and one refused antenatal treatment. All neonates were treated with ZDV. Results: The HIV transmission rate in children born to mothers treated with ZDV was 6.6%. This compares with a transmission rate of 14% before we used ZDV. All three mothers who transmitted infection had low compliance, initiated therapy late in pregnancy or had advanced disease. Conclusion: Our experience supports the idea that ZDV treatment has reduced HIV transmission rate. Copyright © 2001 Elsevier Science Ireland Ltd.

AB - Objective: To determine the rate of mother to child transmission of HIV infection in women treated with zidovudine (ZDV). Patients and methods: A consecutive series of 52 HIV-positive pregnant women who either received antenatal care or delivered at our institution. Forty-three women were known to be HIV positive before delivery. Forty were treated with ZDV, 36 intravenously. Twelve had no antenatal care and one refused antenatal treatment. All neonates were treated with ZDV. Results: The HIV transmission rate in children born to mothers treated with ZDV was 6.6%. This compares with a transmission rate of 14% before we used ZDV. All three mothers who transmitted infection had low compliance, initiated therapy late in pregnancy or had advanced disease. Conclusion: Our experience supports the idea that ZDV treatment has reduced HIV transmission rate. Copyright © 2001 Elsevier Science Ireland Ltd.

KW - Antiretroviral

KW - Perinatal transmission

KW - Pregnancy

KW - Zidovudine

U2 - 10.1016/S0301-2115(00)00499-1

DO - 10.1016/S0301-2115(00)00499-1

M3 - Article

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VL - 97

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JO - European Journal of Obstetrics, Gynecology and Reproductive Biology

JF - European Journal of Obstetrics, Gynecology and Reproductive Biology

IS - 1

ER -

Human immunodeficiency virus infection in pregnant women, transmission and zidovudine therapy

Abstract

Keywords

UN SDGs

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