Human immunodeficiency virus infection does not worsen prognosis of liver transplantation for hepatocellular carcinoma

Fernando Agüero; Alejandro Forner; Christian Manzardo; Andres Valdivieso; Marino Blanes; Rafael Barcena; Antoni Rafecas; Lluis Castells; Manuel Abradelo; Julian Torre-Cisneros; Luisa Gonzalez-Dieguez; Magdalena Salcedo; Trinidad Serrano; Miguel Jimenez-Perez; Jose Ignacio Herrero; Mikel Gastaca; Victoria Aguilera; Juan Fabregat; Santos del Campo; Itxarone Bilbao; Carlos Jimenez Romero; Asuncion Moreno; Antoni Rimola; Jose M. Miro; J. M. Miro; Fernando Agüero; J. Blanch; M. Brunet; D. Calatayud; C. Cervera; G. Crespo; E. de Lazzari; C. Fondevila; A. Forner; J. Fuster; X. Forns; J. C. García-Valdecasas; A. Gil; J. M. Gatell; M. Laguno; A. Lligoña; M. C. Londoño; J. Mallolas; C. Manzardo; M. Monrás; A. Moreno; J. Murillas; M. Navasa; D. Paredes; I. Pérez; C. Tural; M. Tuset; A. Rimola; J. Torre-Cisneros; P. Barrera; J. Briceño; J. J. Caston; G. Costan; M. de la Mata; R. Lara; P. López- Cillero; J. L. Montero; A. Rivero; S. Rufian; F. Suárez; M. A. Castro; S. López; J. D. Pedreira; P. Vázquez; A. Antela; E. Losada; E. Molina; E. Otero; E. Varo; T. Serrano; J. J. Araiz; E. Barrao; J. Larraga; S. Letona; R. Lozano; P. Luque; A. Navarro; I. Sanjoaquín; E. Tejero; M. Salcedo; R. Bañares; J. Berenguer; G. Clemente; J. Cosín; J. P. Ferreiroa; J. L. García-Sabrido; I. Gutiérrez; J. C. López; P. Miralles; M. Ramírez; D. Rincón; M. Sánchez; M. Jiménez; J. de la Cruz; J. L. Fernández

doi:10.1002/hep.28321

Human immunodeficiency virus infection does not worsen prognosis of liver transplantation for hepatocellular carcinoma

Fernando Agüero, Alejandro Forner, Christian Manzardo, Andres Valdivieso, Marino Blanes, Rafael Barcena, Antoni Rafecas, Lluis Castells, Manuel Abradelo, Julian Torre-Cisneros, Luisa Gonzalez-Dieguez, Magdalena Salcedo, Trinidad Serrano, Miguel Jimenez-Perez, Jose Ignacio Herrero, Mikel Gastaca, Victoria Aguilera, Juan Fabregat, Santos del Campo, Itxarone BilbaoCarlos Jimenez Romero, Asuncion Moreno, Antoni Rimola, Jose M. Miro, J. M. Miro, Fernando Agüero, J. Blanch, M. Brunet, D. Calatayud, C. Cervera, G. Crespo, E. de Lazzari, C. Fondevila, A. Forner, J. Fuster, X. Forns, J. C. García-Valdecasas, A. Gil, J. M. Gatell, M. Laguno, A. Lligoña, M. C. Londoño, J. Mallolas, C. Manzardo, M. Monrás, A. Moreno, J. Murillas, M. Navasa, D. Paredes, I. Pérez, C. Tural, M. Tuset, A. Rimola, J. Torre-Cisneros, P. Barrera, J. Briceño, J. J. Caston, G. Costan, M. de la Mata, R. Lara, P. López- Cillero, J. L. Montero, A. Rivero, S. Rufian, F. Suárez, M. A. Castro, S. López, J. D. Pedreira, P. Vázquez, A. Antela, E. Losada, E. Molina, E. Otero, E. Varo, T. Serrano, J. J. Araiz, E. Barrao, J. Larraga, S. Letona, R. Lozano, P. Luque, A. Navarro, I. Sanjoaquín, E. Tejero, M. Salcedo, R. Bañares, J. Berenguer, G. Clemente, J. Cosín, J. P. Ferreiroa, J. L. García-Sabrido, I. Gutiérrez, J. C. López, P. Miralles, M. Ramírez, D. Rincón, M. Sánchez, M. Jiménez, J. de la Cruz, J. L. Fernández

Research output: Contribution to journal › Article › Research › peer-review

16 Citations (Scopus)

Abstract

© 2016 by the American Association for the Study of Liver Diseases. The impact of human immunodeficiency virus (HIV) infection on patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC) is uncertain. This study aimed to assess the outcome of a prospective Spanish nationwide cohort of HIV-infected patients undergoing LT for HCC (2002-2014). These patients were matched (age, gender, year of LT, center, and hepatitis C virus (HCV) or hepatitis B virus infection) with non-HIV-infected controls (1:3 ratio). Patients with incidental HCC were excluded. Seventy-four HIV-infected patients and 222 non-HIV-infected patients were included. All patients had cirrhosis, mostly due to HCV infection (92%). HIV-infected patients were younger (47 versus 51 years) and had undetectable HCV RNA at LT (19% versus 9%) more frequently than non-HIV-infected patients. No significant differences were detected between HIV-infected and non-HIV-infected recipients in the radiological characteristics of HCC at enlisting or in the histopathological findings for HCC in the explanted liver. Survival at 1, 3, and 5 years for HIV-infected versus non-HIV-infected patients was 88% versus 90%, 78% versus 78%, and 67% versus 73% (P = 0.779), respectively. HCV infection (hazard ratio = 7.90, 95% confidence interval 1.07-56.82) and maximum nodule diameter >3 cm in the explanted liver (hazard ratio = 1.72, 95% confidence interval 1.02-2.89) were independently associated with mortality in the whole series. HCC recurred in 12 HIV-infected patients (16%) and 32 non-HIV-infected patients (14%), with a probability of 4% versus 5% at 1 year, 18% versus 12% at 3 years, and 20% versus 19% at 5 years (P = 0.904). Microscopic vascular invasion (hazard ratio = 3.40, 95% confidence interval 1.34-8.64) was the only factor independently associated with HCC recurrence. Conclusions: HIV infection had no impact on recurrence of HCC or survival after LT. Our results support the indication of LT in HIV-infected patients with HCC.

Original language	English
Pages (from-to)	488-498
Journal	Hepatology
Volume	63
Issue number	2
DOIs	https://doi.org/10.1002/hep.28321
Publication status	Published - 1 Feb 2016

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Agüero, F., Forner, A., Manzardo, C., Valdivieso, A., Blanes, M., Barcena, R., Rafecas, A., Castells, L., Abradelo, M., Torre-Cisneros, J., Gonzalez-Dieguez, L., Salcedo, M., Serrano, T., Jimenez-Perez, M., Herrero, J. I., Gastaca, M., Aguilera, V., Fabregat, J., del Campo, S., ... Fernández, J. L. (2016). Human immunodeficiency virus infection does not worsen prognosis of liver transplantation for hepatocellular carcinoma. Hepatology, 63(2), 488-498. https://doi.org/10.1002/hep.28321

Agüero, Fernando ; Forner, Alejandro ; Manzardo, Christian ; Valdivieso, Andres ; Blanes, Marino ; Barcena, Rafael ; Rafecas, Antoni ; Castells, Lluis ; Abradelo, Manuel ; Torre-Cisneros, Julian ; Gonzalez-Dieguez, Luisa ; Salcedo, Magdalena ; Serrano, Trinidad ; Jimenez-Perez, Miguel ; Herrero, Jose Ignacio ; Gastaca, Mikel ; Aguilera, Victoria ; Fabregat, Juan ; del Campo, Santos ; Bilbao, Itxarone ; Romero, Carlos Jimenez ; Moreno, Asuncion ; Rimola, Antoni ; Miro, Jose M. ; Miro, J. M. ; Agüero, Fernando ; Blanch, J. ; Brunet, M. ; Calatayud, D. ; Cervera, C. ; Crespo, G. ; de Lazzari, E. ; Fondevila, C. ; Forner, A. ; Fuster, J. ; Forns, X. ; García-Valdecasas, J. C. ; Gil, A. ; Gatell, J. M. ; Laguno, M. ; Lligoña, A. ; Londoño, M. C. ; Mallolas, J. ; Manzardo, C. ; Monrás, M. ; Moreno, A. ; Murillas, J. ; Navasa, M. ; Paredes, D. ; Pérez, I. ; Tural, C. ; Tuset, M. ; Rimola, A. ; Torre-Cisneros, J. ; Barrera, P. ; Briceño, J. ; Caston, J. J. ; Costan, G. ; de la Mata, M. ; Lara, R. ; López- Cillero, P. ; Montero, J. L. ; Rivero, A. ; Rufian, S. ; Suárez, F. ; Castro, M. A. ; López, S. ; Pedreira, J. D. ; Vázquez, P. ; Antela, A. ; Losada, E. ; Molina, E. ; Otero, E. ; Varo, E. ; Serrano, T. ; Araiz, J. J. ; Barrao, E. ; Larraga, J. ; Letona, S. ; Lozano, R. ; Luque, P. ; Navarro, A. ; Sanjoaquín, I. ; Tejero, E. ; Salcedo, M. ; Bañares, R. ; Berenguer, J. ; Clemente, G. ; Cosín, J. ; Ferreiroa, J. P. ; García-Sabrido, J. L. ; Gutiérrez, I. ; López, J. C. ; Miralles, P. ; Ramírez, M. ; Rincón, D. ; Sánchez, M. ; Jiménez, M. ; de la Cruz, J. ; Fernández, J. L. / Human immunodeficiency virus infection does not worsen prognosis of liver transplantation for hepatocellular carcinoma. In: Hepatology. 2016 ; Vol. 63, No. 2. pp. 488-498.

@article{803f821b91f84595a4b26ff42ba7ff28,

title = "Human immunodeficiency virus infection does not worsen prognosis of liver transplantation for hepatocellular carcinoma",

abstract = "{\textcopyright} 2016 by the American Association for the Study of Liver Diseases. The impact of human immunodeficiency virus (HIV) infection on patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC) is uncertain. This study aimed to assess the outcome of a prospective Spanish nationwide cohort of HIV-infected patients undergoing LT for HCC (2002-2014). These patients were matched (age, gender, year of LT, center, and hepatitis C virus (HCV) or hepatitis B virus infection) with non-HIV-infected controls (1:3 ratio). Patients with incidental HCC were excluded. Seventy-four HIV-infected patients and 222 non-HIV-infected patients were included. All patients had cirrhosis, mostly due to HCV infection (92%). HIV-infected patients were younger (47 versus 51 years) and had undetectable HCV RNA at LT (19% versus 9%) more frequently than non-HIV-infected patients. No significant differences were detected between HIV-infected and non-HIV-infected recipients in the radiological characteristics of HCC at enlisting or in the histopathological findings for HCC in the explanted liver. Survival at 1, 3, and 5 years for HIV-infected versus non-HIV-infected patients was 88% versus 90%, 78% versus 78%, and 67% versus 73% (P = 0.779), respectively. HCV infection (hazard ratio = 7.90, 95% confidence interval 1.07-56.82) and maximum nodule diameter >3 cm in the explanted liver (hazard ratio = 1.72, 95% confidence interval 1.02-2.89) were independently associated with mortality in the whole series. HCC recurred in 12 HIV-infected patients (16%) and 32 non-HIV-infected patients (14%), with a probability of 4% versus 5% at 1 year, 18% versus 12% at 3 years, and 20% versus 19% at 5 years (P = 0.904). Microscopic vascular invasion (hazard ratio = 3.40, 95% confidence interval 1.34-8.64) was the only factor independently associated with HCC recurrence. Conclusions: HIV infection had no impact on recurrence of HCC or survival after LT. Our results support the indication of LT in HIV-infected patients with HCC.",

author = "Fernando Ag{\"u}ero and Alejandro Forner and Christian Manzardo and Andres Valdivieso and Marino Blanes and Rafael Barcena and Antoni Rafecas and Lluis Castells and Manuel Abradelo and Julian Torre-Cisneros and Luisa Gonzalez-Dieguez and Magdalena Salcedo and Trinidad Serrano and Miguel Jimenez-Perez and Herrero, {Jose Ignacio} and Mikel Gastaca and Victoria Aguilera and Juan Fabregat and {del Campo}, Santos and Itxarone Bilbao and Romero, {Carlos Jimenez} and Asuncion Moreno and Antoni Rimola and Miro, {Jose M.} and Miro, {J. M.} and Fernando Ag{\"u}ero and J. Blanch and M. Brunet and D. Calatayud and C. Cervera and G. Crespo and {de Lazzari}, E. and C. Fondevila and A. Forner and J. Fuster and X. Forns and Garc{\'i}a-Valdecasas, {J. C.} and A. Gil and Gatell, {J. M.} and M. Laguno and A. Lligo{\~n}a and Londo{\~n}o, {M. C.} and J. Mallolas and C. Manzardo and M. Monr{\'a}s and A. Moreno and J. Murillas and M. Navasa and D. Paredes and I. P{\'e}rez and C. Tural and M. Tuset and A. Rimola and J. Torre-Cisneros and P. Barrera and J. Brice{\~n}o and Caston, {J. J.} and G. Costan and {de la Mata}, M. and R. Lara and {L{\'o}pez- Cillero}, P. and Montero, {J. L.} and A. Rivero and S. Rufian and F. Su{\'a}rez and Castro, {M. A.} and S. L{\'o}pez and Pedreira, {J. D.} and P. V{\'a}zquez and A. Antela and E. Losada and E. Molina and E. Otero and E. Varo and T. Serrano and Araiz, {J. J.} and E. Barrao and J. Larraga and S. Letona and R. Lozano and P. Luque and A. Navarro and I. Sanjoaqu{\'i}n and E. Tejero and M. Salcedo and R. Ba{\~n}ares and J. Berenguer and G. Clemente and J. Cos{\'i}n and Ferreiroa, {J. P.} and Garc{\'i}a-Sabrido, {J. L.} and I. Guti{\'e}rrez and L{\'o}pez, {J. C.} and P. Miralles and M. Ram{\'i}rez and D. Rinc{\'o}n and M. S{\'a}nchez and M. Jim{\'e}nez and {de la Cruz}, J. and Fern{\'a}ndez, {J. L.}",

year = "2016",

month = feb,

day = "1",

doi = "10.1002/hep.28321",

language = "English",

volume = "63",

pages = "488--498",

journal = "Hepatology",

issn = "0270-9139",

publisher = "John Wiley and Sons Ltd",

number = "2",

}

Agüero, F, Forner, A, Manzardo, C, Valdivieso, A, Blanes, M, Barcena, R, Rafecas, A, Castells, L, Abradelo, M, Torre-Cisneros, J, Gonzalez-Dieguez, L, Salcedo, M, Serrano, T, Jimenez-Perez, M, Herrero, JI, Gastaca, M, Aguilera, V, Fabregat, J, del Campo, S, Bilbao, I, Romero, CJ, Moreno, A, Rimola, A, Miro, JM, Miro, JM, Agüero, F, Blanch, J, Brunet, M, Calatayud, D, Cervera, C, Crespo, G, de Lazzari, E, Fondevila, C, Forner, A, Fuster, J, Forns, X, García-Valdecasas, JC, Gil, A, Gatell, JM, Laguno, M, Lligoña, A, Londoño, MC, Mallolas, J, Manzardo, C, Monrás, M, Moreno, A, Murillas, J, Navasa, M, Paredes, D, Pérez, I, Tural, C, Tuset, M, Rimola, A, Torre-Cisneros, J, Barrera, P, Briceño, J, Caston, JJ, Costan, G, de la Mata, M, Lara, R, López- Cillero, P, Montero, JL, Rivero, A, Rufian, S, Suárez, F, Castro, MA, López, S, Pedreira, JD, Vázquez, P, Antela, A, Losada, E, Molina, E, Otero, E, Varo, E, Serrano, T, Araiz, JJ, Barrao, E, Larraga, J, Letona, S, Lozano, R, Luque, P, Navarro, A, Sanjoaquín, I, Tejero, E, Salcedo, M, Bañares, R, Berenguer, J, Clemente, G, Cosín, J, Ferreiroa, JP, García-Sabrido, JL, Gutiérrez, I, López, JC, Miralles, P, Ramírez, M, Rincón, D, Sánchez, M, Jiménez, M, de la Cruz, J & Fernández, JL 2016, 'Human immunodeficiency virus infection does not worsen prognosis of liver transplantation for hepatocellular carcinoma', Hepatology, vol. 63, no. 2, pp. 488-498. https://doi.org/10.1002/hep.28321

Human immunodeficiency virus infection does not worsen prognosis of liver transplantation for hepatocellular carcinoma. / Agüero, Fernando; Forner, Alejandro; Manzardo, Christian; Valdivieso, Andres; Blanes, Marino; Barcena, Rafael; Rafecas, Antoni; Castells, Lluis; Abradelo, Manuel; Torre-Cisneros, Julian; Gonzalez-Dieguez, Luisa; Salcedo, Magdalena; Serrano, Trinidad; Jimenez-Perez, Miguel; Herrero, Jose Ignacio; Gastaca, Mikel; Aguilera, Victoria; Fabregat, Juan; del Campo, Santos; Bilbao, Itxarone; Romero, Carlos Jimenez; Moreno, Asuncion; Rimola, Antoni; Miro, Jose M.; Miro, J. M.; Agüero, Fernando; Blanch, J.; Brunet, M.; Calatayud, D.; Cervera, C.; Crespo, G.; de Lazzari, E.; Fondevila, C.; Forner, A.; Fuster, J.; Forns, X.; García-Valdecasas, J. C.; Gil, A.; Gatell, J. M.; Laguno, M.; Lligoña, A.; Londoño, M. C.; Mallolas, J.; Manzardo, C.; Monrás, M.; Moreno, A.; Murillas, J.; Navasa, M.; Paredes, D.; Pérez, I.; Tural, C.; Tuset, M.; Rimola, A.; Torre-Cisneros, J.; Barrera, P.; Briceño, J.; Caston, J. J.; Costan, G.; de la Mata, M.; Lara, R.; López- Cillero, P.; Montero, J. L.; Rivero, A.; Rufian, S.; Suárez, F.; Castro, M. A.; López, S.; Pedreira, J. D.; Vázquez, P.; Antela, A.; Losada, E.; Molina, E.; Otero, E.; Varo, E.; Serrano, T.; Araiz, J. J.; Barrao, E.; Larraga, J.; Letona, S.; Lozano, R.; Luque, P.; Navarro, A.; Sanjoaquín, I.; Tejero, E.; Salcedo, M.; Bañares, R.; Berenguer, J.; Clemente, G.; Cosín, J.; Ferreiroa, J. P.; García-Sabrido, J. L.; Gutiérrez, I.; López, J. C.; Miralles, P.; Ramírez, M.; Rincón, D.; Sánchez, M.; Jiménez, M.; de la Cruz, J.; Fernández, J. L.

In: Hepatology, Vol. 63, No. 2, 01.02.2016, p. 488-498.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Human immunodeficiency virus infection does not worsen prognosis of liver transplantation for hepatocellular carcinoma

AU - Agüero, Fernando

AU - Forner, Alejandro

AU - Manzardo, Christian

AU - Valdivieso, Andres

AU - Blanes, Marino

AU - Barcena, Rafael

AU - Rafecas, Antoni

AU - Castells, Lluis

AU - Abradelo, Manuel

AU - Torre-Cisneros, Julian

AU - Gonzalez-Dieguez, Luisa

AU - Salcedo, Magdalena

AU - Serrano, Trinidad

AU - Jimenez-Perez, Miguel

AU - Herrero, Jose Ignacio

AU - Gastaca, Mikel

AU - Aguilera, Victoria

AU - Fabregat, Juan

AU - del Campo, Santos

AU - Bilbao, Itxarone

AU - Romero, Carlos Jimenez

AU - Moreno, Asuncion

AU - Rimola, Antoni

AU - Miro, Jose M.

AU - Miro, J. M.

AU - Agüero, Fernando

AU - Blanch, J.

AU - Brunet, M.

AU - Calatayud, D.

AU - Cervera, C.

AU - Crespo, G.

AU - de Lazzari, E.

AU - Fondevila, C.

AU - Forner, A.

AU - Fuster, J.

AU - Forns, X.

AU - García-Valdecasas, J. C.

AU - Gil, A.

AU - Gatell, J. M.

AU - Laguno, M.

AU - Lligoña, A.

AU - Londoño, M. C.

AU - Mallolas, J.

AU - Manzardo, C.

AU - Monrás, M.

AU - Moreno, A.

AU - Murillas, J.

AU - Navasa, M.

AU - Paredes, D.

AU - Pérez, I.

AU - Tural, C.

AU - Tuset, M.

AU - Rimola, A.

AU - Torre-Cisneros, J.

AU - Barrera, P.

AU - Briceño, J.

AU - Caston, J. J.

AU - Costan, G.

AU - de la Mata, M.

AU - Lara, R.

AU - López- Cillero, P.

AU - Montero, J. L.

AU - Rivero, A.

AU - Rufian, S.

AU - Suárez, F.

AU - Castro, M. A.

AU - López, S.

AU - Pedreira, J. D.

AU - Vázquez, P.

AU - Antela, A.

AU - Losada, E.

AU - Molina, E.

AU - Otero, E.

AU - Varo, E.

AU - Serrano, T.

AU - Araiz, J. J.

AU - Barrao, E.

AU - Larraga, J.

AU - Letona, S.

AU - Lozano, R.

AU - Luque, P.

AU - Navarro, A.

AU - Sanjoaquín, I.

AU - Tejero, E.

AU - Salcedo, M.

AU - Bañares, R.

AU - Berenguer, J.

AU - Clemente, G.

AU - Cosín, J.

AU - Ferreiroa, J. P.

AU - García-Sabrido, J. L.

AU - Gutiérrez, I.

AU - López, J. C.

AU - Miralles, P.

AU - Ramírez, M.

AU - Rincón, D.

AU - Sánchez, M.

AU - Jiménez, M.

AU - de la Cruz, J.

AU - Fernández, J. L.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - © 2016 by the American Association for the Study of Liver Diseases. The impact of human immunodeficiency virus (HIV) infection on patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC) is uncertain. This study aimed to assess the outcome of a prospective Spanish nationwide cohort of HIV-infected patients undergoing LT for HCC (2002-2014). These patients were matched (age, gender, year of LT, center, and hepatitis C virus (HCV) or hepatitis B virus infection) with non-HIV-infected controls (1:3 ratio). Patients with incidental HCC were excluded. Seventy-four HIV-infected patients and 222 non-HIV-infected patients were included. All patients had cirrhosis, mostly due to HCV infection (92%). HIV-infected patients were younger (47 versus 51 years) and had undetectable HCV RNA at LT (19% versus 9%) more frequently than non-HIV-infected patients. No significant differences were detected between HIV-infected and non-HIV-infected recipients in the radiological characteristics of HCC at enlisting or in the histopathological findings for HCC in the explanted liver. Survival at 1, 3, and 5 years for HIV-infected versus non-HIV-infected patients was 88% versus 90%, 78% versus 78%, and 67% versus 73% (P = 0.779), respectively. HCV infection (hazard ratio = 7.90, 95% confidence interval 1.07-56.82) and maximum nodule diameter >3 cm in the explanted liver (hazard ratio = 1.72, 95% confidence interval 1.02-2.89) were independently associated with mortality in the whole series. HCC recurred in 12 HIV-infected patients (16%) and 32 non-HIV-infected patients (14%), with a probability of 4% versus 5% at 1 year, 18% versus 12% at 3 years, and 20% versus 19% at 5 years (P = 0.904). Microscopic vascular invasion (hazard ratio = 3.40, 95% confidence interval 1.34-8.64) was the only factor independently associated with HCC recurrence. Conclusions: HIV infection had no impact on recurrence of HCC or survival after LT. Our results support the indication of LT in HIV-infected patients with HCC.

AB - © 2016 by the American Association for the Study of Liver Diseases. The impact of human immunodeficiency virus (HIV) infection on patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC) is uncertain. This study aimed to assess the outcome of a prospective Spanish nationwide cohort of HIV-infected patients undergoing LT for HCC (2002-2014). These patients were matched (age, gender, year of LT, center, and hepatitis C virus (HCV) or hepatitis B virus infection) with non-HIV-infected controls (1:3 ratio). Patients with incidental HCC were excluded. Seventy-four HIV-infected patients and 222 non-HIV-infected patients were included. All patients had cirrhosis, mostly due to HCV infection (92%). HIV-infected patients were younger (47 versus 51 years) and had undetectable HCV RNA at LT (19% versus 9%) more frequently than non-HIV-infected patients. No significant differences were detected between HIV-infected and non-HIV-infected recipients in the radiological characteristics of HCC at enlisting or in the histopathological findings for HCC in the explanted liver. Survival at 1, 3, and 5 years for HIV-infected versus non-HIV-infected patients was 88% versus 90%, 78% versus 78%, and 67% versus 73% (P = 0.779), respectively. HCV infection (hazard ratio = 7.90, 95% confidence interval 1.07-56.82) and maximum nodule diameter >3 cm in the explanted liver (hazard ratio = 1.72, 95% confidence interval 1.02-2.89) were independently associated with mortality in the whole series. HCC recurred in 12 HIV-infected patients (16%) and 32 non-HIV-infected patients (14%), with a probability of 4% versus 5% at 1 year, 18% versus 12% at 3 years, and 20% versus 19% at 5 years (P = 0.904). Microscopic vascular invasion (hazard ratio = 3.40, 95% confidence interval 1.34-8.64) was the only factor independently associated with HCC recurrence. Conclusions: HIV infection had no impact on recurrence of HCC or survival after LT. Our results support the indication of LT in HIV-infected patients with HCC.

U2 - 10.1002/hep.28321

DO - 10.1002/hep.28321

M3 - Article

VL - 63

SP - 488

EP - 498

JO - Hepatology

JF - Hepatology

SN - 0270-9139

IS - 2

ER -

Human immunodeficiency virus infection does not worsen prognosis of liver transplantation for hepatocellular carcinoma

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