Host and disease factors are associated with cognitive function in European HIV-infected adults prior to initiation of antiretroviral therapy

A. Winston; W. Stöhr; A. Antinori; A. Arenas-Pinto; J. M. Llibre; H. Amieva; A. Cabié; I. Williams; G. Di Perri; M. J. Tellez; J. Rockstroh; A. Babiker; A. Pozniak; F. Raffi; L. Richert; Nikos Dedes; Genevieve Chene; Clotilde Allavena; Brigitte Autran; Raffaella Bucciardini; Stefano Vella; Andrzej Horban; Jose Arribas; Marta Boffito; Deenan Pillay; Xavier Franquet; Siegfried Schwarze; Jesper Grarup; Aurelie Fischer; Cedrick Wallet; Alpha Diallo; Jean Michel Molina; Juliette Saillard; Christiane Moecklinghoff; Hans Jurgen Stellbrink; Remko Leeuwen; Jose Gatell; Eric Sandstrom; Markus Flepp; Fiona Ewings; Elizabeth C. George; Fleur Hudson; Gillian Pearce; Romina Quercia; Felipe Rogatto; Randi Leavitt; Bach Yen Nguyen; Frank Goebel; Simone Marcotullio; Navrup Kaur; Peter Sasieni; Christina Spencer-Drake; Tim Peto; Veronica Miller; Genevieve Chene; Fabien Arnault; Céline Boucherie; Aurélie Fischer; Delphine Jean; Virginie Paniego; Elodie Rouch; Christine Schwimmer; Malika Soussi; Audrey Taieb; Monique Termote; Guillaume Touzeau; Cedrick Wallet; Adam Cursley; Wendy Dodds; Anne Hoppe; Ischa Kummeling; Filippo Pacciarini; Nick Paton; Charlotte Russell; Kay Taylor; Denise Ward; Bitten Aagaard; Marius Eid; Daniela Gey; Birgitte Jensen; Marie Louise Jakobsen; Per O. Jansson; Karoline Jensen; Zillah Joensen; Ellen Larsen; Christiane Pahl; Mary Pearson; Birgit Nielsen; Søren Reilev; Ilse Christ; Desiree Lathouwers; Corry Manting; Bienvenu Mendy; Annie Metro; Sandrine Couffin-Cadiergues; Anne Laure Knellwolf; Lucia Palmisiano; Esther Aznar; Cristina Barea

doi:10.1111/hiv.12344

Host and disease factors are associated with cognitive function in European HIV-infected adults prior to initiation of antiretroviral therapy

A. Winston, W. Stöhr, A. Antinori, A. Arenas-Pinto, J. M. Llibre, H. Amieva, A. Cabié, I. Williams, G. Di Perri, M. J. Tellez, J. Rockstroh, A. Babiker, A. Pozniak, F. Raffi, L. Richert, Nikos Dedes, Genevieve Chene, Clotilde Allavena, Brigitte Autran, Raffaella BucciardiniStefano Vella, Andrzej Horban, Jose Arribas, Marta Boffito, Deenan Pillay, Xavier Franquet, Siegfried Schwarze, Jesper Grarup, Aurelie Fischer, Cedrick Wallet, Alpha Diallo, Jean Michel Molina, Juliette Saillard, Christiane Moecklinghoff, Hans Jurgen Stellbrink, Remko Leeuwen, Jose Gatell, Eric Sandstrom, Markus Flepp, Fiona Ewings, Elizabeth C. George, Fleur Hudson, Gillian Pearce, Romina Quercia, Felipe Rogatto, Randi Leavitt, Bach Yen Nguyen, Frank Goebel, Simone Marcotullio, Navrup Kaur, Peter Sasieni, Christina Spencer-Drake, Tim Peto, Veronica Miller, Genevieve Chene, Fabien Arnault, Céline Boucherie, Aurélie Fischer, Delphine Jean, Virginie Paniego, Elodie Rouch, Christine Schwimmer, Malika Soussi, Audrey Taieb, Monique Termote, Guillaume Touzeau, Cedrick Wallet, Adam Cursley, Wendy Dodds, Anne Hoppe, Ischa Kummeling, Filippo Pacciarini, Nick Paton, Charlotte Russell, Kay Taylor, Denise Ward, Bitten Aagaard, Marius Eid, Daniela Gey, Birgitte Jensen, Marie Louise Jakobsen, Per O. Jansson, Karoline Jensen, Zillah Joensen, Ellen Larsen, Christiane Pahl, Mary Pearson, Birgit Nielsen, Søren Reilev, Ilse Christ, Desiree Lathouwers, Corry Manting, Bienvenu Mendy, Annie Metro, Sandrine Couffin-Cadiergues, Anne Laure Knellwolf, Lucia Palmisiano, Esther Aznar, Cristina Barea

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Abstract

© 2015 British HIV Association Objectives: Deficits in cognitive function remain prevalent in HIV-infected individuals. The aim of this European multicentre study was to assess factors associated with cognitive function in antiretroviral therapy (ART)-naïve HIV-infected subjects at the time of enrolment in the NEAT 001/Agence Nationale de Recherche sur le SIDA (ANRS) 143 study. Methods: Prior to starting ART, seven cognitive tests exploring domains including episodic memory, verbal fluency, executive function and psychomotor speed were administered with scores standardized to z-score using the study population sample mean and standard deviation. The primary measure was overall z-score average (NPZ). We assessed associations between baseline factors and test results using multivariable regression models. Results: Of 283 subjects with baseline cognitive assessments, 90% were male and 12% of black ethnicity. Median (interquartile range) age, years of education, years of known HIV infection, baseline CD4 count and baseline HIV RNA were 39 (31, 47) years, 13 (11, 17) years, 1 (0, 4) years, 344 (279, 410) cells/μL and 4.74 (4.28, 5.14) log10 HIV-1 RNA copies/mL, respectively. Forty per cent were current smokers. Factors significantly associated with poorer overall cognitive performance in multivariable models included older age, shorter duration of education, black ethnicity, lower height, and lower plasma HIV RNA. Conclusions: In this large, European-wide, ART-naïve population with relatively preserved immunity and early HIV infection, cognitive function scores at the time of ART initiation were associated with demographic and HIV-disease factors.

Original language	English
Pages (from-to)	471-478
Journal	HIV Medicine
Volume	17
Issue number	6
DOIs	https://doi.org/10.1111/hiv.12344
Publication status	Published - 1 Jun 2016

Keywords

antiretroviral naïve
cognitive
HIV
neuropsychological tests

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/hiv.12344

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Winston, A., Stöhr, W., Antinori, A., Arenas-Pinto, A., Llibre, J. M., Amieva, H., Cabié, A., Williams, I., Di Perri, G., Tellez, M. J., Rockstroh, J., Babiker, A., Pozniak, A., Raffi, F., Richert, L., Dedes, N., Chene, G., Allavena, C., Autran, B., ... Barea, C. (2016). Host and disease factors are associated with cognitive function in European HIV-infected adults prior to initiation of antiretroviral therapy. HIV Medicine, 17(6), 471-478. https://doi.org/10.1111/hiv.12344

Winston, A. ; Stöhr, W. ; Antinori, A. ; Arenas-Pinto, A. ; Llibre, J. M. ; Amieva, H. ; Cabié, A. ; Williams, I. ; Di Perri, G. ; Tellez, M. J. ; Rockstroh, J. ; Babiker, A. ; Pozniak, A. ; Raffi, F. ; Richert, L. ; Dedes, Nikos ; Chene, Genevieve ; Allavena, Clotilde ; Autran, Brigitte ; Bucciardini, Raffaella ; Vella, Stefano ; Horban, Andrzej ; Arribas, Jose ; Boffito, Marta ; Pillay, Deenan ; Franquet, Xavier ; Schwarze, Siegfried ; Grarup, Jesper ; Fischer, Aurelie ; Wallet, Cedrick ; Diallo, Alpha ; Molina, Jean Michel ; Saillard, Juliette ; Moecklinghoff, Christiane ; Stellbrink, Hans Jurgen ; Leeuwen, Remko ; Gatell, Jose ; Sandstrom, Eric ; Flepp, Markus ; Ewings, Fiona ; George, Elizabeth C. ; Hudson, Fleur ; Pearce, Gillian ; Quercia, Romina ; Rogatto, Felipe ; Leavitt, Randi ; Nguyen, Bach Yen ; Goebel, Frank ; Marcotullio, Simone ; Kaur, Navrup ; Sasieni, Peter ; Spencer-Drake, Christina ; Peto, Tim ; Miller, Veronica ; Chene, Genevieve ; Arnault, Fabien ; Boucherie, Céline ; Fischer, Aurélie ; Jean, Delphine ; Paniego, Virginie ; Rouch, Elodie ; Schwimmer, Christine ; Soussi, Malika ; Taieb, Audrey ; Termote, Monique ; Touzeau, Guillaume ; Wallet, Cedrick ; Cursley, Adam ; Dodds, Wendy ; Hoppe, Anne ; Kummeling, Ischa ; Pacciarini, Filippo ; Paton, Nick ; Russell, Charlotte ; Taylor, Kay ; Ward, Denise ; Aagaard, Bitten ; Eid, Marius ; Gey, Daniela ; Jensen, Birgitte ; Jakobsen, Marie Louise ; Jansson, Per O. ; Jensen, Karoline ; Joensen, Zillah ; Larsen, Ellen ; Pahl, Christiane ; Pearson, Mary ; Nielsen, Birgit ; Reilev, Søren ; Christ, Ilse ; Lathouwers, Desiree ; Manting, Corry ; Mendy, Bienvenu ; Metro, Annie ; Couffin-Cadiergues, Sandrine ; Knellwolf, Anne Laure ; Palmisiano, Lucia ; Aznar, Esther ; Barea, Cristina. / Host and disease factors are associated with cognitive function in European HIV-infected adults prior to initiation of antiretroviral therapy. In: HIV Medicine. 2016 ; Vol. 17, No. 6. pp. 471-478.

@article{f0cec842d7684e1e8859e76661c0a45b,

title = "Host and disease factors are associated with cognitive function in European HIV-infected adults prior to initiation of antiretroviral therapy",

abstract = "{\textcopyright} 2015 British HIV Association Objectives: Deficits in cognitive function remain prevalent in HIV-infected individuals. The aim of this European multicentre study was to assess factors associated with cognitive function in antiretroviral therapy (ART)-na{\"i}ve HIV-infected subjects at the time of enrolment in the NEAT 001/Agence Nationale de Recherche sur le SIDA (ANRS) 143 study. Methods: Prior to starting ART, seven cognitive tests exploring domains including episodic memory, verbal fluency, executive function and psychomotor speed were administered with scores standardized to z-score using the study population sample mean and standard deviation. The primary measure was overall z-score average (NPZ). We assessed associations between baseline factors and test results using multivariable regression models. Results: Of 283 subjects with baseline cognitive assessments, 90% were male and 12% of black ethnicity. Median (interquartile range) age, years of education, years of known HIV infection, baseline CD4 count and baseline HIV RNA were 39 (31, 47) years, 13 (11, 17) years, 1 (0, 4) years, 344 (279, 410) cells/μL and 4.74 (4.28, 5.14) log10 HIV-1 RNA copies/mL, respectively. Forty per cent were current smokers. Factors significantly associated with poorer overall cognitive performance in multivariable models included older age, shorter duration of education, black ethnicity, lower height, and lower plasma HIV RNA. Conclusions: In this large, European-wide, ART-na{\"i}ve population with relatively preserved immunity and early HIV infection, cognitive function scores at the time of ART initiation were associated with demographic and HIV-disease factors.",

keywords = "antiretroviral na{\"i}ve, cognitive, HIV, neuropsychological tests",

author = "A. Winston and W. St{\"o}hr and A. Antinori and A. Arenas-Pinto and Llibre, {J. M.} and H. Amieva and A. Cabi{\'e} and I. Williams and {Di Perri}, G. and Tellez, {M. J.} and J. Rockstroh and A. Babiker and A. Pozniak and F. Raffi and L. Richert and Nikos Dedes and Genevieve Chene and Clotilde Allavena and Brigitte Autran and Raffaella Bucciardini and Stefano Vella and Andrzej Horban and Jose Arribas and Marta Boffito and Deenan Pillay and Xavier Franquet and Siegfried Schwarze and Jesper Grarup and Aurelie Fischer and Cedrick Wallet and Alpha Diallo and Molina, {Jean Michel} and Juliette Saillard and Christiane Moecklinghoff and Stellbrink, {Hans Jurgen} and Remko Leeuwen and Jose Gatell and Eric Sandstrom and Markus Flepp and Fiona Ewings and George, {Elizabeth C.} and Fleur Hudson and Gillian Pearce and Romina Quercia and Felipe Rogatto and Randi Leavitt and Nguyen, {Bach Yen} and Frank Goebel and Simone Marcotullio and Navrup Kaur and Peter Sasieni and Christina Spencer-Drake and Tim Peto and Veronica Miller and Genevieve Chene and Fabien Arnault and C{\'e}line Boucherie and Aur{\'e}lie Fischer and Delphine Jean and Virginie Paniego and Elodie Rouch and Christine Schwimmer and Malika Soussi and Audrey Taieb and Monique Termote and Guillaume Touzeau and Cedrick Wallet and Adam Cursley and Wendy Dodds and Anne Hoppe and Ischa Kummeling and Filippo Pacciarini and Nick Paton and Charlotte Russell and Kay Taylor and Denise Ward and Bitten Aagaard and Marius Eid and Daniela Gey and Birgitte Jensen and Jakobsen, {Marie Louise} and Jansson, {Per O.} and Karoline Jensen and Zillah Joensen and Ellen Larsen and Christiane Pahl and Mary Pearson and Birgit Nielsen and S{\o}ren Reilev and Ilse Christ and Desiree Lathouwers and Corry Manting and Bienvenu Mendy and Annie Metro and Sandrine Couffin-Cadiergues and Knellwolf, {Anne Laure} and Lucia Palmisiano and Esther Aznar and Cristina Barea",

year = "2016",

month = jun,

day = "1",

doi = "10.1111/hiv.12344",

language = "English",

volume = "17",

pages = "471--478",

journal = "HIV Medicine",

issn = "1464-2662",

number = "6",

}

Winston, A, Stöhr, W, Antinori, A, Arenas-Pinto, A, Llibre, JM, Amieva, H, Cabié, A, Williams, I, Di Perri, G, Tellez, MJ, Rockstroh, J, Babiker, A, Pozniak, A, Raffi, F, Richert, L, Dedes, N, Chene, G, Allavena, C, Autran, B, Bucciardini, R, Vella, S, Horban, A, Arribas, J, Boffito, M, Pillay, D, Franquet, X, Schwarze, S, Grarup, J, Fischer, A, Wallet, C, Diallo, A, Molina, JM, Saillard, J, Moecklinghoff, C, Stellbrink, HJ, Leeuwen, R, Gatell, J, Sandstrom, E, Flepp, M, Ewings, F, George, EC, Hudson, F, Pearce, G, Quercia, R, Rogatto, F, Leavitt, R, Nguyen, BY, Goebel, F, Marcotullio, S, Kaur, N, Sasieni, P, Spencer-Drake, C, Peto, T, Miller, V, Chene, G, Arnault, F, Boucherie, C, Fischer, A, Jean, D, Paniego, V, Rouch, E, Schwimmer, C, Soussi, M, Taieb, A, Termote, M, Touzeau, G, Wallet, C, Cursley, A, Dodds, W, Hoppe, A, Kummeling, I, Pacciarini, F, Paton, N, Russell, C, Taylor, K, Ward, D, Aagaard, B, Eid, M, Gey, D, Jensen, B, Jakobsen, ML, Jansson, PO, Jensen, K, Joensen, Z, Larsen, E, Pahl, C, Pearson, M, Nielsen, B, Reilev, S, Christ, I, Lathouwers, D, Manting, C, Mendy, B, Metro, A, Couffin-Cadiergues, S, Knellwolf, AL, Palmisiano, L, Aznar, E & Barea, C 2016, 'Host and disease factors are associated with cognitive function in European HIV-infected adults prior to initiation of antiretroviral therapy', HIV Medicine, vol. 17, no. 6, pp. 471-478. https://doi.org/10.1111/hiv.12344

Host and disease factors are associated with cognitive function in European HIV-infected adults prior to initiation of antiretroviral therapy. / Winston, A.; Stöhr, W.; Antinori, A.; Arenas-Pinto, A.; Llibre, J. M.; Amieva, H.; Cabié, A.; Williams, I.; Di Perri, G.; Tellez, M. J.; Rockstroh, J.; Babiker, A.; Pozniak, A.; Raffi, F.; Richert, L.; Dedes, Nikos; Chene, Genevieve; Allavena, Clotilde; Autran, Brigitte; Bucciardini, Raffaella; Vella, Stefano; Horban, Andrzej; Arribas, Jose; Boffito, Marta; Pillay, Deenan; Franquet, Xavier; Schwarze, Siegfried; Grarup, Jesper; Fischer, Aurelie; Wallet, Cedrick; Diallo, Alpha; Molina, Jean Michel; Saillard, Juliette; Moecklinghoff, Christiane; Stellbrink, Hans Jurgen; Leeuwen, Remko; Gatell, Jose; Sandstrom, Eric; Flepp, Markus; Ewings, Fiona; George, Elizabeth C.; Hudson, Fleur; Pearce, Gillian; Quercia, Romina; Rogatto, Felipe; Leavitt, Randi; Nguyen, Bach Yen; Goebel, Frank; Marcotullio, Simone; Kaur, Navrup; Sasieni, Peter; Spencer-Drake, Christina; Peto, Tim; Miller, Veronica; Chene, Genevieve; Arnault, Fabien; Boucherie, Céline; Fischer, Aurélie; Jean, Delphine; Paniego, Virginie; Rouch, Elodie; Schwimmer, Christine; Soussi, Malika; Taieb, Audrey; Termote, Monique; Touzeau, Guillaume; Wallet, Cedrick; Cursley, Adam; Dodds, Wendy; Hoppe, Anne; Kummeling, Ischa; Pacciarini, Filippo; Paton, Nick; Russell, Charlotte; Taylor, Kay; Ward, Denise; Aagaard, Bitten; Eid, Marius; Gey, Daniela; Jensen, Birgitte; Jakobsen, Marie Louise; Jansson, Per O.; Jensen, Karoline; Joensen, Zillah; Larsen, Ellen; Pahl, Christiane; Pearson, Mary; Nielsen, Birgit; Reilev, Søren; Christ, Ilse; Lathouwers, Desiree; Manting, Corry; Mendy, Bienvenu; Metro, Annie; Couffin-Cadiergues, Sandrine; Knellwolf, Anne Laure; Palmisiano, Lucia; Aznar, Esther; Barea, Cristina.

In: HIV Medicine, Vol. 17, No. 6, 01.06.2016, p. 471-478.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Host and disease factors are associated with cognitive function in European HIV-infected adults prior to initiation of antiretroviral therapy

AU - Winston, A.

AU - Stöhr, W.

AU - Antinori, A.

AU - Arenas-Pinto, A.

AU - Llibre, J. M.

AU - Amieva, H.

AU - Cabié, A.

AU - Williams, I.

AU - Di Perri, G.

AU - Tellez, M. J.

AU - Rockstroh, J.

AU - Babiker, A.

AU - Pozniak, A.

AU - Raffi, F.

AU - Richert, L.

AU - Dedes, Nikos

AU - Chene, Genevieve

AU - Allavena, Clotilde

AU - Autran, Brigitte

AU - Bucciardini, Raffaella

AU - Vella, Stefano

AU - Horban, Andrzej

AU - Arribas, Jose

AU - Boffito, Marta

AU - Pillay, Deenan

AU - Franquet, Xavier

AU - Schwarze, Siegfried

AU - Grarup, Jesper

AU - Fischer, Aurelie

AU - Wallet, Cedrick

AU - Diallo, Alpha

AU - Molina, Jean Michel

AU - Saillard, Juliette

AU - Moecklinghoff, Christiane

AU - Stellbrink, Hans Jurgen

AU - Leeuwen, Remko

AU - Gatell, Jose

AU - Sandstrom, Eric

AU - Flepp, Markus

AU - Ewings, Fiona

AU - George, Elizabeth C.

AU - Hudson, Fleur

AU - Pearce, Gillian

AU - Quercia, Romina

AU - Rogatto, Felipe

AU - Leavitt, Randi

AU - Nguyen, Bach Yen

AU - Goebel, Frank

AU - Marcotullio, Simone

AU - Kaur, Navrup

AU - Sasieni, Peter

AU - Spencer-Drake, Christina

AU - Peto, Tim

AU - Miller, Veronica

AU - Chene, Genevieve

AU - Arnault, Fabien

AU - Boucherie, Céline

AU - Fischer, Aurélie

AU - Jean, Delphine

AU - Paniego, Virginie

AU - Rouch, Elodie

AU - Schwimmer, Christine

AU - Soussi, Malika

AU - Taieb, Audrey

AU - Termote, Monique

AU - Touzeau, Guillaume

AU - Wallet, Cedrick

AU - Cursley, Adam

AU - Dodds, Wendy

AU - Hoppe, Anne

AU - Kummeling, Ischa

AU - Pacciarini, Filippo

AU - Paton, Nick

AU - Russell, Charlotte

AU - Taylor, Kay

AU - Ward, Denise

AU - Aagaard, Bitten

AU - Eid, Marius

AU - Gey, Daniela

AU - Jensen, Birgitte

AU - Jakobsen, Marie Louise

AU - Jansson, Per O.

AU - Jensen, Karoline

AU - Joensen, Zillah

AU - Larsen, Ellen

AU - Pahl, Christiane

AU - Pearson, Mary

AU - Nielsen, Birgit

AU - Reilev, Søren

AU - Christ, Ilse

AU - Lathouwers, Desiree

AU - Manting, Corry

AU - Mendy, Bienvenu

AU - Metro, Annie

AU - Couffin-Cadiergues, Sandrine

AU - Knellwolf, Anne Laure

AU - Palmisiano, Lucia

AU - Aznar, Esther

AU - Barea, Cristina

PY - 2016/6/1

Y1 - 2016/6/1

N2 - © 2015 British HIV Association Objectives: Deficits in cognitive function remain prevalent in HIV-infected individuals. The aim of this European multicentre study was to assess factors associated with cognitive function in antiretroviral therapy (ART)-naïve HIV-infected subjects at the time of enrolment in the NEAT 001/Agence Nationale de Recherche sur le SIDA (ANRS) 143 study. Methods: Prior to starting ART, seven cognitive tests exploring domains including episodic memory, verbal fluency, executive function and psychomotor speed were administered with scores standardized to z-score using the study population sample mean and standard deviation. The primary measure was overall z-score average (NPZ). We assessed associations between baseline factors and test results using multivariable regression models. Results: Of 283 subjects with baseline cognitive assessments, 90% were male and 12% of black ethnicity. Median (interquartile range) age, years of education, years of known HIV infection, baseline CD4 count and baseline HIV RNA were 39 (31, 47) years, 13 (11, 17) years, 1 (0, 4) years, 344 (279, 410) cells/μL and 4.74 (4.28, 5.14) log10 HIV-1 RNA copies/mL, respectively. Forty per cent were current smokers. Factors significantly associated with poorer overall cognitive performance in multivariable models included older age, shorter duration of education, black ethnicity, lower height, and lower plasma HIV RNA. Conclusions: In this large, European-wide, ART-naïve population with relatively preserved immunity and early HIV infection, cognitive function scores at the time of ART initiation were associated with demographic and HIV-disease factors.

AB - © 2015 British HIV Association Objectives: Deficits in cognitive function remain prevalent in HIV-infected individuals. The aim of this European multicentre study was to assess factors associated with cognitive function in antiretroviral therapy (ART)-naïve HIV-infected subjects at the time of enrolment in the NEAT 001/Agence Nationale de Recherche sur le SIDA (ANRS) 143 study. Methods: Prior to starting ART, seven cognitive tests exploring domains including episodic memory, verbal fluency, executive function and psychomotor speed were administered with scores standardized to z-score using the study population sample mean and standard deviation. The primary measure was overall z-score average (NPZ). We assessed associations between baseline factors and test results using multivariable regression models. Results: Of 283 subjects with baseline cognitive assessments, 90% were male and 12% of black ethnicity. Median (interquartile range) age, years of education, years of known HIV infection, baseline CD4 count and baseline HIV RNA were 39 (31, 47) years, 13 (11, 17) years, 1 (0, 4) years, 344 (279, 410) cells/μL and 4.74 (4.28, 5.14) log10 HIV-1 RNA copies/mL, respectively. Forty per cent were current smokers. Factors significantly associated with poorer overall cognitive performance in multivariable models included older age, shorter duration of education, black ethnicity, lower height, and lower plasma HIV RNA. Conclusions: In this large, European-wide, ART-naïve population with relatively preserved immunity and early HIV infection, cognitive function scores at the time of ART initiation were associated with demographic and HIV-disease factors.

KW - antiretroviral naïve

KW - cognitive

KW - HIV

KW - neuropsychological tests

U2 - 10.1111/hiv.12344

DO - 10.1111/hiv.12344

M3 - Article

VL - 17

SP - 471

EP - 478

JO - HIV Medicine

JF - HIV Medicine

SN - 1464-2662

IS - 6

ER -

Host and disease factors are associated with cognitive function in European HIV-infected adults prior to initiation of antiretroviral therapy

Abstract

Keywords

UN SDGs

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