Host and disease factors are associated with cognitive function in European HIV-infected adults prior to initiation of antiretroviral therapy

A. Winston, W. Stöhr, A. Antinori, A. Arenas-Pinto, J. M. Llibre, H. Amieva, A. Cabié, I. Williams, G. Di Perri, M. J. Tellez, J. Rockstroh, A. Babiker, A. Pozniak, F. Raffi, L. Richert, Nikos Dedes, Genevieve Chene, Clotilde Allavena, Brigitte Autran, Raffaella BucciardiniStefano Vella, Andrzej Horban, Jose Arribas, Marta Boffito, Deenan Pillay, Xavier Franquet, Siegfried Schwarze, Jesper Grarup, Aurelie Fischer, Cedrick Wallet, Alpha Diallo, Jean Michel Molina, Juliette Saillard, Christiane Moecklinghoff, Hans Jurgen Stellbrink, Remko Leeuwen, Jose Gatell, Eric Sandstrom, Markus Flepp, Fiona Ewings, Elizabeth C. George, Fleur Hudson, Gillian Pearce, Romina Quercia, Felipe Rogatto, Randi Leavitt, Bach Yen Nguyen, Frank Goebel, Simone Marcotullio, Navrup Kaur, Peter Sasieni, Christina Spencer-Drake, Tim Peto, Veronica Miller, Genevieve Chene, Fabien Arnault, Céline Boucherie, Aurélie Fischer, Delphine Jean, Virginie Paniego, Elodie Rouch, Christine Schwimmer, Malika Soussi, Audrey Taieb, Monique Termote, Guillaume Touzeau, Cedrick Wallet, Adam Cursley, Wendy Dodds, Anne Hoppe, Ischa Kummeling, Filippo Pacciarini, Nick Paton, Charlotte Russell, Kay Taylor, Denise Ward, Bitten Aagaard, Marius Eid, Daniela Gey, Birgitte Jensen, Marie Louise Jakobsen, Per O. Jansson, Karoline Jensen, Zillah Joensen, Ellen Larsen, Christiane Pahl, Mary Pearson, Birgit Nielsen, Søren Reilev, Ilse Christ, Desiree Lathouwers, Corry Manting, Bienvenu Mendy, Annie Metro, Sandrine Couffin-Cadiergues, Anne Laure Knellwolf, Lucia Palmisiano, Esther Aznar, Cristina Barea

    Research output: Contribution to journalArticleResearchpeer-review

    6 Citations (Scopus)

    Abstract

    © 2015 British HIV Association Objectives: Deficits in cognitive function remain prevalent in HIV-infected individuals. The aim of this European multicentre study was to assess factors associated with cognitive function in antiretroviral therapy (ART)-naïve HIV-infected subjects at the time of enrolment in the NEAT 001/Agence Nationale de Recherche sur le SIDA (ANRS) 143 study. Methods: Prior to starting ART, seven cognitive tests exploring domains including episodic memory, verbal fluency, executive function and psychomotor speed were administered with scores standardized to z-score using the study population sample mean and standard deviation. The primary measure was overall z-score average (NPZ). We assessed associations between baseline factors and test results using multivariable regression models. Results: Of 283 subjects with baseline cognitive assessments, 90% were male and 12% of black ethnicity. Median (interquartile range) age, years of education, years of known HIV infection, baseline CD4 count and baseline HIV RNA were 39 (31, 47) years, 13 (11, 17) years, 1 (0, 4) years, 344 (279, 410) cells/μL and 4.74 (4.28, 5.14) log10 HIV-1 RNA copies/mL, respectively. Forty per cent were current smokers. Factors significantly associated with poorer overall cognitive performance in multivariable models included older age, shorter duration of education, black ethnicity, lower height, and lower plasma HIV RNA. Conclusions: In this large, European-wide, ART-naïve population with relatively preserved immunity and early HIV infection, cognitive function scores at the time of ART initiation were associated with demographic and HIV-disease factors.
    Original languageEnglish
    Pages (from-to)471-478
    JournalHIV Medicine
    Volume17
    Issue number6
    DOIs
    Publication statusPublished - 1 Jun 2016

    Keywords

    • antiretroviral naïve
    • cognitive
    • HIV
    • neuropsychological tests

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