Hospitalization due to whooping cough in Spain (1997-2011)

María Isabel Fernández-Cano, Lluís Armadans-Gil, Mercedes Álvarez-Bartolomé, José Ángel Rodrigo-Pendás, Magda Campins-Martí

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14 Citations (Scopus)


© 2013 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved. Introduction: Pertussis incidence has increased in recent years in countries with high vaccination coverage. The aim of this study was to determine the health impact of pertussis in Spain in the period 1997-2011 in relation to hospitalizations, mortality, and associated costs. Methods: We retrospectively analyzed hospital discharges included in the Minimum Data Set (MDS) in Spain for the period 1997-2011, with a primary or secondary diagnosis related to pertussis. We calculated incidence rates of hospitalization for pertussis (per 100,000) per year, by age group and by Autonomous Region, along with the mortality and lethality rates. Results: A total of 8,331 hospital discharges with a diagnosis of pertussis were recorded in Spain between 1997 and 2011. The overall incidence of pertussis hospitalizations was 1.3 cases per 100,000 inhabitants. The large majority (92%) of hospitalizations occurred in children under one year of age, with an incidence of 115.2 hospitalizations per 100,000. There were 47 deaths, 37 (79%) in the group of children under 1 year and 6 (13%) in the group older than 65 years. The estimated cost of hospitalization for pertussis was 1,841 euros. Conclusion: The epidemiology of severe cases of pertussis, and its clinical and economic impact, confirms the need to modify the vaccination strategies for Spain to achieve more effective control in the most vulnerable groups.
Original languageEnglish
Pages (from-to)638-642
JournalEnfermedades Infecciosas y Microbiologia Clinica
Publication statusPublished - 1 Jan 2014


  • Epidemiology
  • Health care surveys
  • Hospitalization
  • National hospital discharge survey
  • Whooping cough


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