Hormonal determinants and effect of ER22/23EK glucocorticoid receptor gene polymorphism on health status deterioration in the participants of the Mataró Ageing Study

Mireia Mora, Lidia Sánchez, Mateu Serra-Prat, Elisabet Palomera, Jesús Blanco, Gloria Aranda, Immaculada Falcón, Immaculada Cadenas, Xavier Boquet, Josep Oriola, Manuel Puig-Domingo

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

The purpose of this study is to assess the potential relationships of circulating IGF-I, adrenal and gonadal steroids, and polymorphism ER22/23EK of the glucocorticoid receptor (GC-R) gene with nutritional, functional and cognitive deterioration in a group of elderly people living independently. This is a population-based prospective study with 313 individuals (160 women and 153 men, 76.7±7 years) who participated. A physical exam, evaluation of functional capacity (Barthel scale), cognitive function (minimental state examination-MMSE), geriatric depression scale (GDS), mininutritional assessment (MNA-SF) and cardiometabolic status were performed at basal time point and at 2 years of follow-up. Biological measurements included cortisol, dehydroepiandrosterone (DHEA), DHEA sulphate, testosterone, estradiol, IGFI and polymorphism ER22/23EK of the GC-R gene. Estradiol was associated with MNA-SF decrease over time (p<0.01, adjusted for age and gender, beta=-0.17, p=0.03). Weight loss was related to testosterone in men (8.6 vs 12.1 pg/ml in no losers; p=0.03), and in women with GDS (13.0% with depression vs 3.3% with no depression; p=0.05) and MMSE (22.2% with cognitive deterioration vs 4.8% with no cognitive deterioration; p=0.049). Barthel decrease was associated with testosterone (p=0.02, after adjusting for age and gender, beta=-0.520, p<0.001), and SHBG (p<0.01, adjusted for age and gender, beta=0.18, p<0.01). DHEA was associated with deterioration in the MMSE (p=0.01, after adjusting for age, gender, GDS scale and academic status, beta=-0.26, p=0.01). Frailty development was related only in men with testosterone levels at the beginning of the study (p=0.017). ER22/23EK was found in 3% of the subjects and carriers had a lower prevalence of hypertension. Adrenal and gonadal steroids are associated to impairment of the ageing health condition in elderly individuals living independently in Spain. ER22/23EK polymorphism of the GC-R gene has a low prevalence in our population. © American Aging Association 2011.
Original languageEnglish
Pages (from-to)553-561
JournalAge
Volume34
Issue number3
DOIs
Publication statusPublished - 1 Jun 2012

Keywords

  • Ageing
  • Cognitive function
  • Depression
  • Frailty
  • Functional capacity
  • Nutritional status
  • Steroidal hormones

Fingerprint Dive into the research topics of 'Hormonal determinants and effect of ER22/23EK glucocorticoid receptor gene polymorphism on health status deterioration in the participants of the Mataró Ageing Study'. Together they form a unique fingerprint.

Cite this