Homozygosity of the T allele of the 46 C→T polymorphism in the F12 gene is a risk factor for acute coronary artery disease in the Spanish population

Amparo Santamaría Ortiz, Antonio Martínez-Rubio, José Mateo, Isabel Tirado, José M. Soria, Jordi Fontcuberta

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    Abstract

    Following new guidelines that contain recommendations on the desirable features of a genetic association study, we performed a case-control study to establish the risk of acute coronary artery disease (CAD) related to the polymorphism (46 C→T) in the F12 gene. We found a 6-fold higher risk of acute CAD associated with the homozygosity of the T allele of the F12, 46C→T polymorphism in the Spanish population.
    Original languageEnglish
    Pages (from-to)878-879
    JournalHaematologica
    Volume89
    Issue number7
    Publication statusPublished - 1 Jul 2004

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