Homozygosity of the T allele of the 46 C→T polymorphism in the F12 gene is a risk factor for acute coronary artery disease in the Spanish population

Amparo Santamaría Ortiz; Antonio Martínez-Rubio; José Mateo; Isabel Tirado; José M. Soria; Jordi Fontcuberta

Homozygosity of the T allele of the 46 C→T polymorphism in the F12 gene is a risk factor for acute coronary artery disease in the Spanish population

Amparo Santamaría Ortiz, Antonio Martínez-Rubio, José Mateo, Isabel Tirado, José M. Soria, Jordi Fontcuberta

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Following new guidelines that contain recommendations on the desirable features of a genetic association study, we performed a case-control study to establish the risk of acute coronary artery disease (CAD) related to the polymorphism (46 C→T) in the F12 gene. We found a 6-fold higher risk of acute CAD associated with the homozygosity of the T allele of the F12, 46C→T polymorphism in the Spanish population.

Original language	English
Pages (from-to)	878-879
Journal	Haematologica
Volume	89
Issue number	7
Publication status	Published - 1 Jul 2004

Cite this

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title = "Homozygosity of the T allele of the 46 C→T polymorphism in the F12 gene is a risk factor for acute coronary artery disease in the Spanish population",

abstract = "Following new guidelines that contain recommendations on the desirable features of a genetic association study, we performed a case-control study to establish the risk of acute coronary artery disease (CAD) related to the polymorphism (46 C→T) in the F12 gene. We found a 6-fold higher risk of acute CAD associated with the homozygosity of the T allele of the F12, 46C→T polymorphism in the Spanish population.",

author = "{Santamar{\'i}a Ortiz}, Amparo and Antonio Mart{\'i}nez-Rubio and Jos{\'e} Mateo and Isabel Tirado and Soria, {Jos{\'e} M.} and Jordi Fontcuberta",

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TY - JOUR

T1 - Homozygosity of the T allele of the 46 C→T polymorphism in the F12 gene is a risk factor for acute coronary artery disease in the Spanish population

AU - Santamaría Ortiz, Amparo

AU - Martínez-Rubio, Antonio

AU - Mateo, José

AU - Tirado, Isabel

AU - Soria, José M.

AU - Fontcuberta, Jordi

PY - 2004/7/1

Y1 - 2004/7/1

N2 - Following new guidelines that contain recommendations on the desirable features of a genetic association study, we performed a case-control study to establish the risk of acute coronary artery disease (CAD) related to the polymorphism (46 C→T) in the F12 gene. We found a 6-fold higher risk of acute CAD associated with the homozygosity of the T allele of the F12, 46C→T polymorphism in the Spanish population.

AB - Following new guidelines that contain recommendations on the desirable features of a genetic association study, we performed a case-control study to establish the risk of acute coronary artery disease (CAD) related to the polymorphism (46 C→T) in the F12 gene. We found a 6-fold higher risk of acute CAD associated with the homozygosity of the T allele of the F12, 46C→T polymorphism in the Spanish population.

M3 - Article

SN - 0390-6078

VL - 89

SP - 878

EP - 879

JO - Haematologica

JF - Haematologica

IS - 7

ER -

Homozygosity of the T allele of the 46 C→T polymorphism in the F12 gene is a risk factor for acute coronary artery disease in the Spanish population

Abstract

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