Following new guidelines that contain recommendations on the desirable features of a genetic association study, we performed a case-control study to establish the risk of acute coronary artery disease (CAD) related to the polymorphism (46 C→T) in the F12 gene. We found a 6-fold higher risk of acute CAD associated with the homozygosity of the T allele of the F12, 46C→T polymorphism in the Spanish population.
|Publication status||Published - 1 Jul 2004|
Santamaría Ortiz, A., Martínez-Rubio, A., Mateo, J., Tirado, I., Soria, J. M., & Fontcuberta, J. (2004). Homozygosity of the T allele of the 46 C→T polymorphism in the F12 gene is a risk factor for acute coronary artery disease in the Spanish population. Haematologica, 89(7), 878-879.