© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Cryptospirolepine is the most structurally complex alkaloid discovered and characterized thus far from any Cryptolepis specie. Characterization of several degradants of the original, sealed NMR sample a decade after the initial report called the validity of the originally proposed structure in question. We now report the development of improved, homodecoupled variants of the 1,1- and 1,n-ADEQUATE (HD-ADEQUATE) NMR experiments; utilization of these techniques was critical to successfully resolving long-standing structural questions associated with crytospirolepine.
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - 1 Aug 2015|
- cryptolepis alkaloids
- DFT calculations
- NMR spectroscopy