© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Cryptospirolepine is the most structurally complex alkaloid discovered and characterized thus far from any Cryptolepis specie. Characterization of several degradants of the original, sealed NMR sample a decade after the initial report called the validity of the originally proposed structure in question. We now report the development of improved, homodecoupled variants of the 1,1- and 1,n-ADEQUATE (HD-ADEQUATE) NMR experiments; utilization of these techniques was critical to successfully resolving long-standing structural questions associated with crytospirolepine.
- cryptolepis alkaloids
- DFT calculations
- NMR spectroscopy
Saurí, J., Bermel, W., Buevich, A. V., Sherer, E. C., Joyce, L. A., Sharaf, M. H. M., Schiff, P. L., Parella, T., Williamson, R. T., & Martin, G. E. (2015). Homodecoupled 1,1- and 1,n-ADEQUATE: Pivotal NMR Experiments for the Structure Revision of Cryptospirolepine. Angewandte Chemie - International Edition, 54(35), 10160-10164. https://doi.org/10.1002/anie.201502540