Hodgkin's disease in patients infected by the human immunodeficiency virus. Study of fifteen cases

José Tomás Navarro, Josep Maria Ribera, Javier Grau, Carolina Frías, Manuel Vaquero, Guillermo Sirera, Montserrat Batlle, Fuensanta Millá, Evarist Feliu

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4 Citations (Scopus)

Abstract

Background: In spite of not being considered as an AIDS defining illnes, Hodgkin's disease (HD) has specific clinical and biological features in HIV-infected patients. Patients and methods: Study of clinicopathologic and analytic characteristics, Epstein-Barr virus (EBV) detection (polymerase chain reaction), and prognosis in 15 patients with HD and HIV infection. Results: Thirteen patients had B symptoms, 10 extranodal involvement and 12 advanced HD. The most frequent histologic subtypes were mixed cellularity (6) and lymphocyte depletion (6). The mean (SD) of CD4 lymphocytes was 0.10 (0.08) × 109/l. The presence of EBV in lymph node biopsy was demonstrated in 3 out of 4 patients investigated. Complete remission (CR) was achieved in 7 out of 14 treated cases (50%), the median overall survival was 26 months and the 2 year event-free survival probability was 60%. Conclussions: In HIV-infected patients, HD presents in advanced stages, unfavourable histologic subtypes, frequent extranodal involvement and B symptoms. The prognosis is poor, mainly because of a low CR rate.
Original languageEnglish
Pages (from-to)19-21
JournalMedicina Clinica
Volume114
Issue number1
Publication statusPublished - 15 Jan 2000

Keywords

  • HIV
  • Hodgkin's disease
  • Prognosis

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