HLA-DR4 as a predictor of outcome three years after onset of rheumatoid arthritis

A. J. Silman*, J. Reeback, D. Jaraquemada

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)


Data from 59 patients with early rheumatoid arthritis were analysed to determine the predictive value of the possession of HLA-DR4 for disease severity and functional outcome at 3 years after disease onset. The previously reported association of that antigen with seropositive disease was confirmed. Conversely, however, there was no evidence that functional outcome was worse in the HLA-DR4 positive group as measured by the Stanford Health Assessment Questionnaire. The mean articular index was lower in the HLA-DR4 group which also had a smaller proportion with limited wrist extension. In addition, both patient and physicians' global assessment of disease status were better in the HLA-DR4 group. It is concluded that HLA-DR4 is not a useful predictor of poor outcome at 3 years.

Original languageEnglish
Pages (from-to)233-235
Number of pages3
JournalRheumatology International
Issue number5
Publication statusPublished - Sep 1986


  • Disability
  • Genetics
  • HLA seropositivity
  • Natural history
  • Rheumatoid arthritis


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