Abstract
Homozygosity for a 32. bp deletion in CCR5 (CCR5-Δ32/Δ32) is associated with strong resistance against HIV-1 infection. Several HLA types have been associated to improved viral control and/or delayed progression to AIDS. We report a unique HIV-1 infected individual homozygous for CCR5-Δ32/Δ32 and carrier of HLA-A*2402 and HLA-B*5701. In comparison with earlier data and although a replication competent virus has been isolated, the patient presents better immune status, response to treatment and disease evolution, which may be related to the control exerted by HLA class I restricted T cell immunity. Importantly, the accumulation of protective factors does not warrant a complete protection to HIV infection and the subsequent life-long treatment. © 2012 Elsevier GmbH.
Original language | English |
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Pages (from-to) | 543-547 |
Journal | Immunobiology |
Volume | 218 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Apr 2013 |
Keywords
- CCR5-Δ32
- Disease progression
- HLA
- Treatment outcome