HLA class I protective alleles in an HIV-1-infected subject homozygous for CCR5-Δ32/Δ32

Ester Ballana, Eva Riveira-Munoz, Christian Pou, Vanessa Bach, Mariona Parera, Marc Noguera, José R. Santos, Roger Badia, Maria Casadellà, Bonaventura Clotet, Roger Paredes, Miguel Angel Martínez, Christian Brander, José A. Esté

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)


Homozygosity for a 32. bp deletion in CCR5 (CCR5-Δ32/Δ32) is associated with strong resistance against HIV-1 infection. Several HLA types have been associated to improved viral control and/or delayed progression to AIDS. We report a unique HIV-1 infected individual homozygous for CCR5-Δ32/Δ32 and carrier of HLA-A*2402 and HLA-B*5701. In comparison with earlier data and although a replication competent virus has been isolated, the patient presents better immune status, response to treatment and disease evolution, which may be related to the control exerted by HLA class I restricted T cell immunity. Importantly, the accumulation of protective factors does not warrant a complete protection to HIV infection and the subsequent life-long treatment. © 2012 Elsevier GmbH.
Original languageEnglish
Pages (from-to)543-547
Issue number4
Publication statusPublished - 1 Apr 2013


  • CCR5-Δ32
  • Disease progression
  • HLA
  • Treatment outcome


Dive into the research topics of 'HLA class I protective alleles in an HIV-1-infected subject homozygous for CCR5-Δ32/Δ32'. Together they form a unique fingerprint.

Cite this