HIV infection, bone metabolism, and fractures

Robert Güerri-Fernández, Judit Villar-García, Adolfo Díez-Pérez, Daniel Prieto-Alhambra

Research output: Contribution to journalReview articleResearchpeer-review

12 Citations (Scopus)


With the advent of high active antiretroviral therapy there was a significant improvement on HIV subjects survival. Thus, bone changes related to HIV became an important aspect of these individuals. HIV affects bone remodeling causing bone fragility. In addition, antiretroviral therapy may also negatively affect bone metabolism. Several studies describe an increased incidence of fractures in these patients when compared with controls without the disease. The European Society of AIDS (EACS), and other societies, have included guidance on management of osteoporosis in HIV-infected patients emphasizing the identification of patients with low bone mass. Supplementation of calcium and vitamin D and the use of alendronate in these individuals should be recommended on a case base. © ABE&M todos os direitos reservados.
Original languageEnglish
Pages (from-to)478-483
JournalArquivos Brasileiros de Endocrinologia e Metabologia
Issue number5
Publication statusPublished - 1 Jan 2014


  • Bone
  • Bone fractures
  • Bone metabolism
  • HIV


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