HIV-1 infected patients older than 50 years. PISCIS cohort study

G. Navarro; M. M. Nogueras; F. Segura; J. Casabona; J. M. Miro; J. Murillas; C. Tural; E. Ferrer; A. Jaén; L. Force; J. Vilaró; I. García; A. Masabeu; J. Altés; A. Esteve; O. Sued; M. Riera; B. Clotet; D. Podzamczer; J. M. Gatell

doi:10.1016/j.jinf.2008.05.003

HIV-1 infected patients older than 50 years. PISCIS cohort study

G. Navarro, M. M. Nogueras, F. Segura, J. Casabona, J. M. Miro, J. Murillas, C. Tural, E. Ferrer, A. Jaén, L. Force, J. Vilaró, I. García, A. Masabeu, J. Altés, A. Esteve, O. Sued, M. Riera, B. Clotet, D. Podzamczer, J. M. Gatell

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

Objective: The aim of this study is to characterize the ways in which older HIV-infected people differ from younger HIV-infected people. Methods: Prospective cohort study. PISCIS cohort includes newly attended HIV-infected subjects since January 1, 1998. Naïve patients were selected. Two groups were defined: G1 (≥50 years at time of diagnosis, n = 493) and G2 (18-49 years, n = 4511). Statistical analysis was performed using χ2, Student's t test, Cox regression and linear mixed models. Results: G1 had different features: males (G1: 84% vs. G2: 75%, p < 0.001), sexual transmission (52% vs. 32%, p < 0.001), AIDS at first visit (38% vs. 22%, p < 0.001). The follow-up was 6 years. Ninety-five percent of patients in G1 and 92% in G2 presented a detectable viral load (≥500 copies/mm3) at the first visit (p = 0.016). G1 presented lower CD4 levels with respect to G2 throughout the period but the increase of CD4 in G1 at the end of the study period was 254 cells/mm3 whereas for G2 it was 196 cells/mm3 (p < 0.001). Mortality was 9% for G1 and 4% for G2 (p < 0.001). Conclusions: HIV-infected people diagnosed at the age of 50 years or older showed different features. They showed good viral and immunological response to HAART. © 2008 The British Infection Society.

Original language	English
Pages (from-to)	64-71
Journal	Journal of Infection
Volume	57
Issue number	1
DOIs	https://doi.org/10.1016/j.jinf.2008.05.003
Publication status	Published - 1 Jul 2008

Keywords

HAART
Older patients
PISCIS cohort

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Navarro, G., Nogueras, M. M., Segura, F., Casabona, J., Miro, J. M., Murillas, J., Tural, C., Ferrer, E., Jaén, A., Force, L., Vilaró, J., García, I., Masabeu, A., Altés, J., Esteve, A., Sued, O., Riera, M., Clotet, B., Podzamczer, D., & Gatell, J. M. (2008). HIV-1 infected patients older than 50 years. PISCIS cohort study. Journal of Infection, 57(1), 64-71. https://doi.org/10.1016/j.jinf.2008.05.003

Navarro, G. ; Nogueras, M. M. ; Segura, F. ; Casabona, J. ; Miro, J. M. ; Murillas, J. ; Tural, C. ; Ferrer, E. ; Jaén, A. ; Force, L. ; Vilaró, J. ; García, I. ; Masabeu, A. ; Altés, J. ; Esteve, A. ; Sued, O. ; Riera, M. ; Clotet, B. ; Podzamczer, D. ; Gatell, J. M. / HIV-1 infected patients older than 50 years. PISCIS cohort study. In: Journal of Infection. 2008 ; Vol. 57, No. 1. pp. 64-71.

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title = "HIV-1 infected patients older than 50 years. PISCIS cohort study",

abstract = "Objective: The aim of this study is to characterize the ways in which older HIV-infected people differ from younger HIV-infected people. Methods: Prospective cohort study. PISCIS cohort includes newly attended HIV-infected subjects since January 1, 1998. Na{\"i}ve patients were selected. Two groups were defined: G1 (≥50 years at time of diagnosis, n = 493) and G2 (18-49 years, n = 4511). Statistical analysis was performed using χ2, Student's t test, Cox regression and linear mixed models. Results: G1 had different features: males (G1: 84% vs. G2: 75%, p < 0.001), sexual transmission (52% vs. 32%, p < 0.001), AIDS at first visit (38% vs. 22%, p < 0.001). The follow-up was 6 years. Ninety-five percent of patients in G1 and 92% in G2 presented a detectable viral load (≥500 copies/mm3) at the first visit (p = 0.016). G1 presented lower CD4 levels with respect to G2 throughout the period but the increase of CD4 in G1 at the end of the study period was 254 cells/mm3 whereas for G2 it was 196 cells/mm3 (p < 0.001). Mortality was 9% for G1 and 4% for G2 (p < 0.001). Conclusions: HIV-infected people diagnosed at the age of 50 years or older showed different features. They showed good viral and immunological response to HAART. {\textcopyright} 2008 The British Infection Society.",

keywords = "HAART, Older patients, PISCIS cohort",

author = "G. Navarro and Nogueras, {M. M.} and F. Segura and J. Casabona and Miro, {J. M.} and J. Murillas and C. Tural and E. Ferrer and A. Ja{\'e}n and L. Force and J. Vilar{\'o} and I. Garc{\'i}a and A. Masabeu and J. Alt{\'e}s and A. Esteve and O. Sued and M. Riera and B. Clotet and D. Podzamczer and Gatell, {J. M.}",

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language = "English",

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Navarro, G, Nogueras, MM, Segura, F, Casabona, J, Miro, JM, Murillas, J, Tural, C, Ferrer, E, Jaén, A, Force, L, Vilaró, J, García, I, Masabeu, A, Altés, J, Esteve, A, Sued, O, Riera, M, Clotet, B, Podzamczer, D & Gatell, JM 2008, 'HIV-1 infected patients older than 50 years. PISCIS cohort study', Journal of Infection, vol. 57, no. 1, pp. 64-71. https://doi.org/10.1016/j.jinf.2008.05.003

HIV-1 infected patients older than 50 years. PISCIS cohort study. / Navarro, G.; Nogueras, M. M.; Segura, F.; Casabona, J.; Miro, J. M.; Murillas, J.; Tural, C.; Ferrer, E.; Jaén, A.; Force, L.; Vilaró, J.; García, I.; Masabeu, A.; Altés, J.; Esteve, A.; Sued, O.; Riera, M.; Clotet, B.; Podzamczer, D.; Gatell, J. M.

In: Journal of Infection, Vol. 57, No. 1, 01.07.2008, p. 64-71.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - HIV-1 infected patients older than 50 years. PISCIS cohort study

AU - Navarro, G.

AU - Nogueras, M. M.

AU - Segura, F.

AU - Casabona, J.

AU - Miro, J. M.

AU - Murillas, J.

AU - Tural, C.

AU - Ferrer, E.

AU - Jaén, A.

AU - Force, L.

AU - Vilaró, J.

AU - García, I.

AU - Masabeu, A.

AU - Altés, J.

AU - Esteve, A.

AU - Sued, O.

AU - Riera, M.

AU - Clotet, B.

AU - Podzamczer, D.

AU - Gatell, J. M.

PY - 2008/7/1

Y1 - 2008/7/1

N2 - Objective: The aim of this study is to characterize the ways in which older HIV-infected people differ from younger HIV-infected people. Methods: Prospective cohort study. PISCIS cohort includes newly attended HIV-infected subjects since January 1, 1998. Naïve patients were selected. Two groups were defined: G1 (≥50 years at time of diagnosis, n = 493) and G2 (18-49 years, n = 4511). Statistical analysis was performed using χ2, Student's t test, Cox regression and linear mixed models. Results: G1 had different features: males (G1: 84% vs. G2: 75%, p < 0.001), sexual transmission (52% vs. 32%, p < 0.001), AIDS at first visit (38% vs. 22%, p < 0.001). The follow-up was 6 years. Ninety-five percent of patients in G1 and 92% in G2 presented a detectable viral load (≥500 copies/mm3) at the first visit (p = 0.016). G1 presented lower CD4 levels with respect to G2 throughout the period but the increase of CD4 in G1 at the end of the study period was 254 cells/mm3 whereas for G2 it was 196 cells/mm3 (p < 0.001). Mortality was 9% for G1 and 4% for G2 (p < 0.001). Conclusions: HIV-infected people diagnosed at the age of 50 years or older showed different features. They showed good viral and immunological response to HAART. © 2008 The British Infection Society.

AB - Objective: The aim of this study is to characterize the ways in which older HIV-infected people differ from younger HIV-infected people. Methods: Prospective cohort study. PISCIS cohort includes newly attended HIV-infected subjects since January 1, 1998. Naïve patients were selected. Two groups were defined: G1 (≥50 years at time of diagnosis, n = 493) and G2 (18-49 years, n = 4511). Statistical analysis was performed using χ2, Student's t test, Cox regression and linear mixed models. Results: G1 had different features: males (G1: 84% vs. G2: 75%, p < 0.001), sexual transmission (52% vs. 32%, p < 0.001), AIDS at first visit (38% vs. 22%, p < 0.001). The follow-up was 6 years. Ninety-five percent of patients in G1 and 92% in G2 presented a detectable viral load (≥500 copies/mm3) at the first visit (p = 0.016). G1 presented lower CD4 levels with respect to G2 throughout the period but the increase of CD4 in G1 at the end of the study period was 254 cells/mm3 whereas for G2 it was 196 cells/mm3 (p < 0.001). Mortality was 9% for G1 and 4% for G2 (p < 0.001). Conclusions: HIV-infected people diagnosed at the age of 50 years or older showed different features. They showed good viral and immunological response to HAART. © 2008 The British Infection Society.

KW - HAART

KW - Older patients

KW - PISCIS cohort

U2 - 10.1016/j.jinf.2008.05.003

DO - 10.1016/j.jinf.2008.05.003

M3 - Article

VL - 57

SP - 64

EP - 71

JO - Journal of Infection

JF - Journal of Infection

SN - 0163-4453

IS - 1

ER -