HIV-1 infected patients older than 50 years. PISCIS cohort study

G. Navarro, M. M. Nogueras, F. Segura, J. Casabona, J. M. Miro, J. Murillas, C. Tural, E. Ferrer, A. Jaén, L. Force, J. Vilaró, I. García, A. Masabeu, J. Altés, A. Esteve, O. Sued, M. Riera, B. Clotet, D. Podzamczer, J. M. Gatell

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Abstract

Objective: The aim of this study is to characterize the ways in which older HIV-infected people differ from younger HIV-infected people. Methods: Prospective cohort study. PISCIS cohort includes newly attended HIV-infected subjects since January 1, 1998. Naïve patients were selected. Two groups were defined: G1 (≥50 years at time of diagnosis, n = 493) and G2 (18-49 years, n = 4511). Statistical analysis was performed using χ2, Student's t test, Cox regression and linear mixed models. Results: G1 had different features: males (G1: 84% vs. G2: 75%, p < 0.001), sexual transmission (52% vs. 32%, p < 0.001), AIDS at first visit (38% vs. 22%, p < 0.001). The follow-up was 6 years. Ninety-five percent of patients in G1 and 92% in G2 presented a detectable viral load (≥500 copies/mm3) at the first visit (p = 0.016). G1 presented lower CD4 levels with respect to G2 throughout the period but the increase of CD4 in G1 at the end of the study period was 254 cells/mm3 whereas for G2 it was 196 cells/mm3 (p < 0.001). Mortality was 9% for G1 and 4% for G2 (p < 0.001). Conclusions: HIV-infected people diagnosed at the age of 50 years or older showed different features. They showed good viral and immunological response to HAART. © 2008 The British Infection Society.
Original languageEnglish
Pages (from-to)64-71
JournalJournal of Infection
Volume57
Issue number1
DOIs
Publication statusPublished - 1 Jul 2008

Keywords

  • HAART
  • Older patients
  • PISCIS cohort

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