HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells

Maria Pino, Itziar Erkizia, Susana Benet, Elina Erikson, Maria Teresa Fernández-Figueras, Dolores Guerrero, Judith Dalmau, Dan Ouchi, Antonio Rausell, Angela Ciuffi, Oliver T. Keppler, Amalio Telenti, Hans Georg Kräusslich, Javier Martinez-Picado, Nuria Izquierdo-Useros

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Abstract

© 2015 Pino et al. Background: Myeloid cells are key players in the recognition and response of the host against invading viruses. Paradoxically, upon HIV-1 infection, myeloid cells might also promote viral pathogenesis through trans-infection, a mechanism that promotes HIV-1 transmission to target cells via viral capture and storage. The receptor Siglec-1 (CD169) potently enhances HIV-1 trans-infection and is regulated by immune activating signals present throughout the course of HIV-1 infection, such as interferon α (IFNα). Results: Here we show that IFNα-activated dendritic cells, monocytes and macrophages have an enhanced ability to capture and trans-infect HIV-1 via Siglec-1 recognition of viral membrane gangliosides. Monocytes from untreated HIV-1-infected individuals trans-infect HIV-1 via Siglec-1, but this capacity diminishes after effective antiretroviral treatment. Furthermore, Siglec-1 is expressed on myeloid cells residing in lymphoid tissues, where it can mediate viral trans-infection. Conclusions: Siglec-1 on myeloid cells could fuel novel CD4+ T-cell infections and contribute to HIV-1 dissemination in vivo.
Original languageEnglish
Article number37
JournalRetrovirology
Volume12
Issue number1
DOIs
Publication statusPublished - 7 May 2015

Keywords

  • Dendritic cells
  • HIV-1
  • Siglec-1
  • Trans-infection

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