TY - JOUR
T1 - HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1
AU - Izquierdo-Useros, Nuria
AU - Lorizate, Maier
AU - McLaren, Paul J.
AU - Telenti, Amalio
AU - Kräusslich, Hans Georg
AU - Martinez-Picado, Javier
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans-infection, a mechanism that promotes viral capture and transmission to target cells, especially after DC maturation. In this review, we highlight recent evidence identifying sialyllactose-containing gangliosides in the viral membrane and the cellular lectin Siglec-1 as critical determinants for HIV-1 capture and storage by mature DCs and for DC-mediated trans-infection of T cells. In contrast, DC-SIGN, long considered to be the main receptor for DC capture of HIV-1, plays a minor role in mature DC-mediated HIV-1 capture and trans-infection. © 2014 Izquierdo-Useros et al.
AB - Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans-infection, a mechanism that promotes viral capture and transmission to target cells, especially after DC maturation. In this review, we highlight recent evidence identifying sialyllactose-containing gangliosides in the viral membrane and the cellular lectin Siglec-1 as critical determinants for HIV-1 capture and storage by mature DCs and for DC-mediated trans-infection of T cells. In contrast, DC-SIGN, long considered to be the main receptor for DC capture of HIV-1, plays a minor role in mature DC-mediated HIV-1 capture and trans-infection. © 2014 Izquierdo-Useros et al.
U2 - https://doi.org/10.1371/journal.ppat.1004146
DO - https://doi.org/10.1371/journal.ppat.1004146
M3 - Review article
VL - 10
JO - PLoS Pathogens
JF - PLoS Pathogens
SN - 1553-7366
IS - 7
M1 - e1004146
ER -
