HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1

Nuria Izquierdo-Useros; Maier Lorizate; Paul J. McLaren; Amalio Telenti; Hans Georg Kräusslich; Javier Martinez-Picado

doi:https://doi.org/10.1371/journal.ppat.1004146

HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1

Nuria Izquierdo-Useros, Maier Lorizate, Paul J. McLaren, Amalio Telenti, Hans Georg Kräusslich, Javier Martinez-Picado

Department of Medicine

Research output: Contribution to journal › Review article › Research › peer-review

58 Citations (Scopus)

Abstract

Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans-infection, a mechanism that promotes viral capture and transmission to target cells, especially after DC maturation. In this review, we highlight recent evidence identifying sialyllactose-containing gangliosides in the viral membrane and the cellular lectin Siglec-1 as critical determinants for HIV-1 capture and storage by mature DCs and for DC-mediated trans-infection of T cells. In contrast, DC-SIGN, long considered to be the main receptor for DC capture of HIV-1, plays a minor role in mature DC-mediated HIV-1 capture and trans-infection. © 2014 Izquierdo-Useros et al.

Original language	English
Article number	e1004146
Journal	PLoS Pathogens
Volume	10
Issue number	7
DOIs	https://doi.org/10.1371/journal.ppat.1004146
Publication status	Published - 1 Jan 2014

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title = "HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1",

abstract = "Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans-infection, a mechanism that promotes viral capture and transmission to target cells, especially after DC maturation. In this review, we highlight recent evidence identifying sialyllactose-containing gangliosides in the viral membrane and the cellular lectin Siglec-1 as critical determinants for HIV-1 capture and storage by mature DCs and for DC-mediated trans-infection of T cells. In contrast, DC-SIGN, long considered to be the main receptor for DC capture of HIV-1, plays a minor role in mature DC-mediated HIV-1 capture and trans-infection. {\textcopyright} 2014 Izquierdo-Useros et al.",

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HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1. / Izquierdo-Useros, Nuria; Lorizate, Maier; McLaren, Paul J.; Telenti, Amalio; Kräusslich, Hans Georg; Martinez-Picado, Javier.

In: PLoS Pathogens, Vol. 10, No. 7, e1004146, 01.01.2014.

Research output: Contribution to journal › Review article › Research › peer-review

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AU - Izquierdo-Useros, Nuria

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AU - Telenti, Amalio

AU - Kräusslich, Hans Georg

AU - Martinez-Picado, Javier

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