Histone h1 post-translational modifications: Update and future perspectives

Marta Andrés, Daniel García-Gomis, Inma Ponte, Pedro Suau, Alicia Roque*

*Corresponding author for this work

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

Histone H1 is the most variable histone and its role at the epigenetic level is less characterized than that of core histones. In vertebrates, H1 is a multigene family, which can encode up to 11 subtypes. The H1 subtype composition is different among cell types during the cell cycle and differentiation. Mass spectrometry–based proteomics has added a new layer of complexity with the identification of a large number of post-translational modifications (PTMs) in H1. In this review, we summarize histone H1 PTMs from lower eukaryotes to humans, with a particular focus on mammalian PTMs. Special emphasis is made on PTMs, whose molecular function has been described. Post-translational modifications in H1 have been associated with the regulation of chromatin structure during the cell cycle as well as transcriptional activation, DNA damage response, and cellular differentiation. Additionally, PTMs in histone H1 that have been linked to diseases such as cancer, autoimmune disorders, and viral infection are examined. Future perspectives and challenges in the profiling of histone H1 PTMs are also discussed.

Original languageAmerican English
Article number5941
Pages (from-to)1-22
Number of pages22
JournalInternational Journal of Molecular Sciences
Volume21
Issue number16
DOIs
Publication statusPublished - 2 Aug 2020

Keywords

  • Acetylation
  • Chromatin structure
  • Citrullination
  • Disease
  • Histone H1
  • Mass spectrometry
  • Methylation
  • Phosphorylation
  • PTM function
  • Ubiquitylation

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