Histamine modulation of glutamate release from hippocampal synaptosomes

F. Javier Rodriguez, Monica Lluch, Josep Dot, Isaac Blanco, José Rodriguez-Alvarez

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17 Citations (Scopus)


Histamine is widely believed to act as a neuromodulator in the central nervous system. Histaminergic fibers arriving at the hippocampus could be involved in the modulation of glutamatergic neurotransmission. Therefore, we have investigated the effect of histamine on [3H]glutamate release from hippocampal synaptosomes by using a superfusion system. Calcium-dependent [3H]glutamate release was stimulated by KCl or 4-aminopyridine. When submaximal concentrations of the depolarizing agents were used (15 mM KCl or 50 μM 4-aminopyridine), histamine, acting via histamine H1 and H2 receptors, produced a concentration dependent increase in the evoked release of glutamate. Maximal effect was obtained with 500 μM histamine. Histamine (up to 1 mM) did not modify basal release. These data suggest that histaminergic afferents may modulate activity-dependent glutamatergic presynaptic terminals in the hippocampus.
Original languageEnglish
Pages (from-to)283-286
JournalEuropean Journal of Pharmacology
Publication statusPublished - 4 Apr 1997


  • Glutamate
  • Hippocampus
  • Histamine
  • Synaptosome
  • [ H]Glutamate, release 3

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