Highly stereoselective synthesis of novel cyclobutane-fused azanucleosides

Ramon Flores, Ramon Alibés, Marta Figueredo, Josep Font

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

Stereoselective syntheses of several 3-azabicyclo[3.2.0]heptane nucleoside analogues have been efficiently completed starting from a homochiral a,b-unsaturated-g-lactam. The target compounds were prepared by condensation of a common bicyclic acetate intermediate with pyrimidine and purine bases under modified Vorbrüggen conditions. The anti-HIV activity of the newly synthesized azanucleosides has been evaluated. © 2009 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)6912-6917
JournalTetrahedron
Volume65
Issue number34
DOIs
Publication statusPublished - 22 Aug 2009

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