Highly resolved HSQC experiments for the fast and accurate measurement of homonuclear and heteronuclear coupling constants

Alexandre A. Souza, Roberto R. Gil, Teodor Parella

    Research output: Contribution to journalArticleResearchpeer-review

    4 Citations (Scopus)

    Abstract

    © 2017 Elsevier Inc. A number of J-upscaled NMR experiments are currently available to measure coupling constants along the indirect F1 dimension of a 2D spectrum. A major drawback is the limited F1 digital resolution that requires long acquisition times in order to achieve reasonably accurate measures. Here is shown how high levels of F1 digital resolution in a multiple-purpose HSQC experiment can be easily achieved by implementing a general J/δ-scaling strategy. In particular, a set of new J-resolved HSQC experiments is presented for a faster and much more accurate J determination in small molecules. Several options and practical aspects are discussed and exemplified by measuring the magnitude and/or the sign of several homo- and heteronuclear coupling constants in one shot.
    Original languageEnglish
    Pages (from-to)54-61
    JournalJournal of Magnetic Resonance
    Volume282
    DOIs
    Publication statusPublished - 1 Sep 2017

    Keywords

    • 1 2 J / J -resolved HSQC CH HH
    • 1 J -resolved HSQC CH
    • 1,n J -resolved HSQC CH
    • 1,n J /J -resolved HSQC CH HH
    • E.COSY
    • J-resolved
    • J-resolved HSQC
    • Proton-carbon coupling constants
    • Proton-proton coupling constants
    • n J -resolved HSQC CH
    • n J /J -resolved HSQC CH HH

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