Highly permeable polylactide-caprolactone nerve guides enhance peripheral nerve regeneration through long gaps

Francisco J. Rodríguez, Nuria Gómez, Gabriele Perego, Xavier Navarro

Research output: Contribution to journalArticleResearchpeer-review

146 Citations (Scopus)

Abstract

We compared regeneration and functional reinnervation after sciatic nerve resection and tubulization repair with bioresorbable guides of poly(L-lactide-co-ε-caprolactone) (PLC) and permanent guides of polysulfone (POS) with different degrees of permeability, leaving a 6 mm gap in different groups of mice. Functional reinnervation was assessed to determine recovery of motor, sensory and sweating functions in the hindpaw during four months postoperation. Highly permeable PLC guides allowed for faster and higher levels of reinnervation for the four functions tested than impermeable or low-permeable PLC guides, while semipermeable 30 and 100 kDa POS tubes yielded very low levels of reinnervation. The regeneration success rate was higher with PLC than with POS tubes. Morphometrical analysis of cross-sectional nerves under light microscopy showed the highest number of regenerated myelinated fibers at mid tube and distal nerve in high-permeable PLC guides. Impermeable PLC guides allowed slightly worse levels of regeneration, while low-permeable PLC guides promoted neuroma and limited distal regeneration. The lowest number of regenerated fibers were found in POS tubes. In summary, highly permeable bioresorbable PLC guides offer a suitable alternative for repairing long gaps in injured nerves, approaching the success of autologous nerve grafts.
Original languageEnglish
Pages (from-to)1489-1500
JournalBiomaterials
Volume20
DOIs
Publication statusPublished - 1 Aug 1999

Keywords

  • Bioresorbable guide
  • Morphometry
  • Nerve regeneration
  • Permeable guide
  • Reinnervation
  • Tube repair

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