Highly efficient and diastereoselective synthesis of (+)-lineatin

Ramon Alibés, Pedro De March, Marta Figueredo, Josep Font, Marta Racamonde, Teodor Parella

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Abstract

A linear sequence was used to synthesize (+)-lineatin in 14 steps and 14% overall yield from a homochiral 2(5H)-furanone. Key steps of this synthetic approach feature the diastereoselective construction of a cyclobutene through a photochemical [2 + 2] cycloaddition and a regiocontrolled oxymercuration reaction.
Original languageEnglish
Pages (from-to)1449-1452
JournalOrganic Letters
Volume6
Issue number9
DOIs
Publication statusPublished - 29 Apr 2004

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