Abstract
A linear sequence was used to synthesize (+)-lineatin in 14 steps and 14% overall yield from a homochiral 2(5H)-furanone. Key steps of this synthetic approach feature the diastereoselective construction of a cyclobutene through a photochemical [2 + 2] cycloaddition and a regiocontrolled oxymercuration reaction.
Original language | English |
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Pages (from-to) | 1449-1452 |
Journal | Organic Letters |
Volume | 6 |
Issue number | 9 |
DOIs | |
Publication status | Published - 29 Apr 2004 |