Highlights of the 2nd International Symposium on Tribbles and Diseases: Tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer

Bing Cui, Patrcik A Eyers, Leonard L Dobens, Jose Miguel Lizcano De Vega, Zhuowei Hu

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The Tribbles (TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2nd International Symposium on Tribbles and Diseases held on May 7‒9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases
Original languageEnglish
Article number DOI: 10.1016/j.apsb.2018.12.007
Pages (from-to)443-454
Number of pages12
JournalActa Pharmacologica Sinica
Volume9
Issue number2
Publication statusPublished - Mar 2019

Keywords

  • cancer
  • Tribbles pseudokinases
  • Protein kinase
  • METABOLISM

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