TY - JOUR
T1 - High Serum Retinol as a Relevant Contributor to Low Bone Mineral Density in Postmenopausal Osteoporotic Women
AU - Navarro-Valverde, Cristina
AU - Caballero-Villarraso, Javier
AU - Mata-Granados, José M.
AU - Casado-Díaz, Antonio
AU - Sosa-Henríquez, Manuel
AU - Malouf-Sierra, Jorge
AU - Nogués-Solán, Xavier
AU - Rodríguez-Mañas, Leocadio
AU - Cortés-Gil, Xavier
AU - Delgadillo-Duarte, Joaquín
AU - Quesada-Gómez, José Manuel
PY - 2018/6/1
Y1 - 2018/6/1
N2 - © 2018, Springer Science+Business Media, LLC, part of Springer Nature. There is controversial information about the impact of vitamin A on bone. Some epidemiological studies show that excessive intake of vitamin A, or an excess of serum vitamin A, has related with adverse impact on bone mass; however, other studies did not find these links, and some authors have proposed that this vitamin might promote a better bone health. The present work aims to contribute to clarify the real role of vitamin A in bone tissue. For this purpose, a cross-sectional study of 154 osteoporotic non-treated postmenopausal women (> 65 years old) was carried out. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry. We assessed concentrations of serum retinol, osteocalcin, parathyroid hormone, alkaline phosphatase, calcium, and phosphorus. We also studied demographic and anthropometric parameters. Spearman’s correlations between retinol levels and other variables found negative correlations with BMD in both lumbar spine (R = − 0.162, P < 0.01) and femoral neck (R = − 0.182, P < 0.01), as well as alkaline phosphatase (R = − 0.110; P < 0.05) and phosphorus (R = − 0.110; P < 0.05). A positive correlation between retinol and fertile window was observed (R = 0.158; P < 0.01). After multivariable adjustment, we still found a negative correlation between serum retinol and BMD, both at the lumbar spine (R = − 0.210; P < 0.01) and at the femoral neck (R = − 0.324, P < 0.001). It is concluded that elevated serum-retinol levels are associated with an increased risk of low bone mass and thus with osteoporotic fractures. Therefore, osteoporosis-risk assessment should include quantification of serum metabolite of vitamin A.
AB - © 2018, Springer Science+Business Media, LLC, part of Springer Nature. There is controversial information about the impact of vitamin A on bone. Some epidemiological studies show that excessive intake of vitamin A, or an excess of serum vitamin A, has related with adverse impact on bone mass; however, other studies did not find these links, and some authors have proposed that this vitamin might promote a better bone health. The present work aims to contribute to clarify the real role of vitamin A in bone tissue. For this purpose, a cross-sectional study of 154 osteoporotic non-treated postmenopausal women (> 65 years old) was carried out. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry. We assessed concentrations of serum retinol, osteocalcin, parathyroid hormone, alkaline phosphatase, calcium, and phosphorus. We also studied demographic and anthropometric parameters. Spearman’s correlations between retinol levels and other variables found negative correlations with BMD in both lumbar spine (R = − 0.162, P < 0.01) and femoral neck (R = − 0.182, P < 0.01), as well as alkaline phosphatase (R = − 0.110; P < 0.05) and phosphorus (R = − 0.110; P < 0.05). A positive correlation between retinol and fertile window was observed (R = 0.158; P < 0.01). After multivariable adjustment, we still found a negative correlation between serum retinol and BMD, both at the lumbar spine (R = − 0.210; P < 0.01) and at the femoral neck (R = − 0.324, P < 0.001). It is concluded that elevated serum-retinol levels are associated with an increased risk of low bone mass and thus with osteoporotic fractures. Therefore, osteoporosis-risk assessment should include quantification of serum metabolite of vitamin A.
KW - Bone health
KW - Bone mass
KW - Osteoporosis
KW - Osteoporotic risk
KW - Retinol
KW - Vitamin A
U2 - 10.1007/s00223-017-0379-8
DO - 10.1007/s00223-017-0379-8
M3 - Article
VL - 102
SP - 651
EP - 656
JO - Calcified Tissue International
JF - Calcified Tissue International
SN - 0171-967X
IS - 6
ER -