TY - JOUR
T1 - High prevalence of upper urinary tract involvement detected by 111indium-oxine leukocyte scintigraphy in patients with candiduria
AU - Horcajada, J. P.
AU - Gutiérrez-Cuadra, M.
AU - Martínez-Rodríguez, I.
AU - Salas, C.
AU - Parra, J. A.
AU - Benito, N.
AU - Quirce, R.
AU - Carril, J. M.
AU - Fariñas, M. C.
N1 - Funding Information:
Some strengths of this study may be highlighted. Patients were selected if heavy candiduria (>104 cfu/mL) was present. Treatment trials funded by the National Institutes of Health (NIH) generally use a lower cutoff (103 cfu/mL) for the definition of candiduria [4]. Moreover, a second positive analysis (urine culture or sediment observation of abundant yeasts) was required in our study. Also, patients underwent several strict exclusion criteria in order to discard patients with renal injury or inflammation of origin other than candiduria. The evaluation of images was made by two experienced and masked radiologists.
Funding Information:
Acknowledgments This work was supported by a grant from the Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain, and by a grant from the Fundación Mutua Médica Madrileña Madrid, Spain.
Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012/3
Y1 - 2012/3
N2 - The purpose of this investigation was to assess the prevalence of upper urinary tract involvement in patients with candiduria by means of 111indium-oxine-labeled leukocyte scintigraphy. An observational cohort study of patients with confirmed candiduria was conducted in an acute-care teaching hospital in Spain from March 2006 through February 2009. An 111In-labeled leukocyte scan was performed in order to assess the upper urinary tract involvement. A series of non-matched patients without candiduria nor bacteriuria undergoing scintigraphy to exclude infections in other sites than the urinary tract was also studied. Demographics, baseline illness, and clinical data were recorded. Candiduria was detected in 428 patients, and scintigraphy was performed in 35 of these patients. Twenty-nine patients without candiduria nor bacteriuria were also studied. Positive renal scintigraphy was documented in 24 (68%) patients with confirmed candiduria and in 3 (10%) patients without candiduria (p∈<∈0.005). Renal uptake was not associated with a higher mortality nor with re-admissions. Subclinical pyelonephritis could be more frequent in patients with candiduria than it has been previously considered.
AB - The purpose of this investigation was to assess the prevalence of upper urinary tract involvement in patients with candiduria by means of 111indium-oxine-labeled leukocyte scintigraphy. An observational cohort study of patients with confirmed candiduria was conducted in an acute-care teaching hospital in Spain from March 2006 through February 2009. An 111In-labeled leukocyte scan was performed in order to assess the upper urinary tract involvement. A series of non-matched patients without candiduria nor bacteriuria undergoing scintigraphy to exclude infections in other sites than the urinary tract was also studied. Demographics, baseline illness, and clinical data were recorded. Candiduria was detected in 428 patients, and scintigraphy was performed in 35 of these patients. Twenty-nine patients without candiduria nor bacteriuria were also studied. Positive renal scintigraphy was documented in 24 (68%) patients with confirmed candiduria and in 3 (10%) patients without candiduria (p∈<∈0.005). Renal uptake was not associated with a higher mortality nor with re-admissions. Subclinical pyelonephritis could be more frequent in patients with candiduria than it has been previously considered.
UR - http://www.scopus.com/inward/record.url?scp=84857049190&partnerID=8YFLogxK
U2 - 10.1007/s10096-011-1299-6
DO - 10.1007/s10096-011-1299-6
M3 - Artículo
C2 - 21633831
AN - SCOPUS:84857049190
SN - 0934-9723
VL - 31
SP - 237
EP - 242
JO - European Journal of Clinical Microbiology and Infectious Diseases
JF - European Journal of Clinical Microbiology and Infectious Diseases
IS - 3
ER -
