An amino pentenoate and an unsaturated oxazolone have shown to be suitable homochiral dienophiles to be reacted with electron-rich heterosubstituted dienes. High-pressure and thermal activation have been studied for these cycloadditions. The adducts obtained are polyfunctional building blocks useful for the synthesis of enantiopure cyclohexane amino acids and related products.
|Publication status||Published - 1 Jan 1996|
Ortuño, R. M., Ibarzo, J., D'Angelo, J., Dumas, F., Alvarez-Larena, A., & Piníella, J. F. (1996). High-pressure and thermally induced asymmetric Diels-Alder cycloadditions of heterosubstituted dienes to homochiral α,β-didehydro amino acid derivatives. Tetrahedron Asymmetry, 7, 127-138. https://doi.org/10.1016/0957-4166(95)00429-7