High precision mapping of kidney stones using μ-IR spectroscopy to determine urinary lithogenesis

Francisco Blanco, Pilar Ortiz-Alías, Montserrat López-Mesas, Manuel Valiente

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Evolution of urinary lithiasis is determined by the metabolism and life-style of the related patient. The appropriate classification of the stone is mandatory for the identification of the lithogenic process. In this study, cros-sections from a single stone of each of the most frequent urolithiasis types (calcium oxalate mono and dihydrate and carbonate apatite) have been selected and imaged using IR microspectroscopy. Moreover, the use of high definition sFTIR (synchrotron source) has revealed hidden information to the conventional FTIR. This work has demonstrated that minor components become key factors on the description of the stages of stone formation. Intensity map for COM (1630 cm<sup>-1</sup> peak). The high spatial definition achieved is key for the precise description of the kidney stone history.
Original languageEnglish
Pages (from-to)457-465
JournalJournal of Biophotonics
Volume8
Issue number6
DOIs
Publication statusPublished - 1 Jan 2015

Keywords

  • Chemical imaging
  • IR microspectroscopy
  • Kidney stones analysis
  • Mapping

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