High precision mapping of kidney stones using μ-IR spectroscopy to determine urinary lithogenesis

Francisco Blanco; Pilar Ortiz-Alías; Montserrat López-Mesas; Manuel Valiente

doi:10.1002/jbio.201300201

High precision mapping of kidney stones using μ-IR spectroscopy to determine urinary lithogenesis

Francisco Blanco, Pilar Ortiz-Alías, Montserrat López-Mesas, Manuel Valiente

Department of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

11 Citations (Scopus)

Abstract

© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Evolution of urinary lithiasis is determined by the metabolism and life-style of the related patient. The appropriate classification of the stone is mandatory for the identification of the lithogenic process. In this study, cros-sections from a single stone of each of the most frequent urolithiasis types (calcium oxalate mono and dihydrate and carbonate apatite) have been selected and imaged using IR microspectroscopy. Moreover, the use of high definition sFTIR (synchrotron source) has revealed hidden information to the conventional FTIR. This work has demonstrated that minor components become key factors on the description of the stages of stone formation. Intensity map for COM (1630 cm<sup>-1</sup> peak). The high spatial definition achieved is key for the precise description of the kidney stone history.

Original language	English
Pages (from-to)	457-465
Journal	Journal of Biophotonics
Volume	8
Issue number	6
DOIs	https://doi.org/10.1002/jbio.201300201
Publication status	Published - 1 Jan 2015

Keywords

Chemical imaging
IR microspectroscopy
Kidney stones analysis
Mapping

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title = "High precision mapping of kidney stones using μ-IR spectroscopy to determine urinary lithogenesis",

abstract = "{\textcopyright} 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Evolution of urinary lithiasis is determined by the metabolism and life-style of the related patient. The appropriate classification of the stone is mandatory for the identification of the lithogenic process. In this study, cros-sections from a single stone of each of the most frequent urolithiasis types (calcium oxalate mono and dihydrate and carbonate apatite) have been selected and imaged using IR microspectroscopy. Moreover, the use of high definition sFTIR (synchrotron source) has revealed hidden information to the conventional FTIR. This work has demonstrated that minor components become key factors on the description of the stages of stone formation. Intensity map for COM (1630 cm-1 peak). The high spatial definition achieved is key for the precise description of the kidney stone history.",

keywords = "Chemical imaging, IR microspectroscopy, Kidney stones analysis, Mapping",

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T1 - High precision mapping of kidney stones using μ-IR spectroscopy to determine urinary lithogenesis

AU - Blanco, Francisco

AU - Ortiz-Alías, Pilar

AU - López-Mesas, Montserrat

AU - Valiente, Manuel

PY - 2015/1/1

Y1 - 2015/1/1

N2 - © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Evolution of urinary lithiasis is determined by the metabolism and life-style of the related patient. The appropriate classification of the stone is mandatory for the identification of the lithogenic process. In this study, cros-sections from a single stone of each of the most frequent urolithiasis types (calcium oxalate mono and dihydrate and carbonate apatite) have been selected and imaged using IR microspectroscopy. Moreover, the use of high definition sFTIR (synchrotron source) has revealed hidden information to the conventional FTIR. This work has demonstrated that minor components become key factors on the description of the stages of stone formation. Intensity map for COM (1630 cm-1 peak). The high spatial definition achieved is key for the precise description of the kidney stone history.

AB - © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Evolution of urinary lithiasis is determined by the metabolism and life-style of the related patient. The appropriate classification of the stone is mandatory for the identification of the lithogenic process. In this study, cros-sections from a single stone of each of the most frequent urolithiasis types (calcium oxalate mono and dihydrate and carbonate apatite) have been selected and imaged using IR microspectroscopy. Moreover, the use of high definition sFTIR (synchrotron source) has revealed hidden information to the conventional FTIR. This work has demonstrated that minor components become key factors on the description of the stages of stone formation. Intensity map for COM (1630 cm-1 peak). The high spatial definition achieved is key for the precise description of the kidney stone history.

KW - Chemical imaging

KW - IR microspectroscopy

KW - Kidney stones analysis

KW - Mapping

U2 - 10.1002/jbio.201300201

DO - 10.1002/jbio.201300201

M3 - Article

SN - 1864-063X

VL - 8

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EP - 465

JO - Journal of Biophotonics

JF - Journal of Biophotonics

IS - 6

ER -

High precision mapping of kidney stones using μ-IR spectroscopy to determine urinary lithogenesis

Abstract

Keywords

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