Higgs boson decays mediated by flavor changing neutral currents (FCNC) are very much suppressed in the Standard Model, at the level of 10-15 for Higgs boson masses of a few hundred GeV. Therefore, any experimental vestige of them would immediately call for new physics. In this paper we consider the FCNC decays of Higgs bosons into a top quark in a general two-Higgs-doublet model (2HDM). The isolated top quark signature, unbalanced by any other heavy particle, should help to identify the potential FCNC events much more than any other final state. We compute the maximum branching ratios and the number of FCNC Higgs boson decay events at the LHC collider at CERN. The most favorable mode for production and subsequent FCNC decay is the lightest CP-even state in the Type II 2HDM, followed by the other CP-even state, if it is not very heavy, whereas the CP-odd mode can never be sufficiently enhanced. Our calculation shows that the branching ratios of the CP-even states may reach 10-5, and that several hundred events could be collected in the highest luminosity runs of the LHC. We also point out some strategies to use these FCNC decays as a handle to discriminate between 2HDM and supersymmetric Higgs bosons. © 2003 Elsevier B.V. All rights reserved.