Heterogeneity in Response to MCT and Psychoeducation :: A Feasibility Study Using Latent Class Mixed Models in First-Episode Psychosis

Marta Ferrer-Quintero; Daniel Fernández; Raquel López-Carrilero; L Díaz-Cutraro; Marina Verdaguer-Rodríguez; Helena García-Mieres; Elena Huerta-Ramos; Juana Gómez-Benito; Trini Peláez; Irene Birulés; Ana Barajas Vélez; Esther Pousa; María Luisa Barrigón; Alfonso Gutiérrez-Zotes; Eva Grasa; Isabel Ruiz-Delgado; Esther Lorente-Rovira; Jordi Cid Colom; Susana Ochoa

doi:10.3390/healthcare10112155

Heterogeneity in Response to MCT and Psychoeducation : A Feasibility Study Using Latent Class Mixed Models in First-Episode Psychosis

Marta Ferrer-Quintero, Daniel Fernández, Raquel López-Carrilero, L Díaz-Cutraro, Marina Verdaguer-Rodríguez, Helena García-Mieres, Elena Huerta-Ramos, Juana Gómez-Benito, Trini Peláez, Irene Birulés, Ana Barajas Vélez, Esther Pousa, María Luisa Barrigón, Alfonso Gutiérrez-Zotes, Eva Grasa, Isabel Ruiz-Delgado, Esther Lorente-Rovira, Jordi Cid Colom, Susana Ochoa

Research output: Contribution to journal › Article › Research › peer-review

4 Citations (Scopus)

Abstract

Metacognitive training (MCT) is an effective treatment for psychosis. Longitudinal trajectories of treatment response are unknown but could point to strategies to maximize treatment efficacy during the first episodes. This work aims to explore the possible benefit of using latent class mixed models (LCMMs) to understand how treatment response differs between metacognitive training and psychoeducation. We conducted LCMMs in 28 patients that received MCT and 34 patients that received psychoeducation. We found that MCT is effective in improving cognitive insight in all patients but that these effects wane at follow-up. In contrast, psychoeducation does not improve cognitive insight, and may increase self-certainty in a group of patients. These results suggest that LCMMs are valuable tools that can aid in treatment prescription and in predicting response to specific treatments.

Original language	English
Journal	Healthcare
Volume	10
DOIs	https://doi.org/10.3390/healthcare10112155
Publication status	Published - 2022

Keywords

First-episode psychosis
Social cognition
Metacognition
Latent class mixed models
Metacognitive training
Psychoeducation

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10.3390/healthcare10112155

https://ddd.uab.cat/record/269156

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Ferrer-Quintero, M., Fernández, D., López-Carrilero, R., Díaz-Cutraro, L., Verdaguer-Rodríguez, M., García-Mieres, H., Huerta-Ramos, E., Gómez-Benito, J., Peláez, T., Birulés, I., Barajas Vélez, A., Pousa, E., Barrigón, M. L., Gutiérrez-Zotes, A., Grasa, E., Ruiz-Delgado, I., Lorente-Rovira, E., Cid Colom, J., & Ochoa, S. (2022). Heterogeneity in Response to MCT and Psychoeducation : A Feasibility Study Using Latent Class Mixed Models in First-Episode Psychosis. Healthcare, 10. https://doi.org/10.3390/healthcare10112155

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title = "Heterogeneity in Response to MCT and Psychoeducation :: A Feasibility Study Using Latent Class Mixed Models in First-Episode Psychosis",

abstract = "Metacognitive training (MCT) is an effective treatment for psychosis. Longitudinal trajectories of treatment response are unknown but could point to strategies to maximize treatment efficacy during the first episodes. This work aims to explore the possible benefit of using latent class mixed models (LCMMs) to understand how treatment response differs between metacognitive training and psychoeducation. We conducted LCMMs in 28 patients that received MCT and 34 patients that received psychoeducation. We found that MCT is effective in improving cognitive insight in all patients but that these effects wane at follow-up. In contrast, psychoeducation does not improve cognitive insight, and may increase self-certainty in a group of patients. These results suggest that LCMMs are valuable tools that can aid in treatment prescription and in predicting response to specific treatments.",

keywords = "First-episode psychosis, Social cognition, Metacognition, Latent class mixed models, Metacognitive training, Psychoeducation",

author = "Marta Ferrer-Quintero and Daniel Fern{\'a}ndez and Raquel L{\'o}pez-Carrilero and L D{\'i}az-Cutraro and Marina Verdaguer-Rodr{\'i}guez and Helena Garc{\'i}a-Mieres and Elena Huerta-Ramos and Juana G{\'o}mez-Benito and Trini Pel{\'a}ez and Irene Birul{\'e}s and \{Barajas V{\'e}lez\}, Ana and Esther Pousa and Barrig{\'o}n, \{Mar{\'i}a Luisa\} and Alfonso Guti{\'e}rrez-Zotes and Eva Grasa and Isabel Ruiz-Delgado and Esther Lorente-Rovira and \{Cid Colom\}, Jordi and Susana Ochoa",

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doi = "10.3390/healthcare10112155",

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Ferrer-Quintero, M, Fernández, D, López-Carrilero, R, Díaz-Cutraro, L, Verdaguer-Rodríguez, M, García-Mieres, H, Huerta-Ramos, E, Gómez-Benito, J, Peláez, T, Birulés, I, Barajas Vélez, A, Pousa, E, Barrigón, ML, Gutiérrez-Zotes, A, Grasa, E, Ruiz-Delgado, I, Lorente-Rovira, E, Cid Colom, J & Ochoa, S 2022, 'Heterogeneity in Response to MCT and Psychoeducation : A Feasibility Study Using Latent Class Mixed Models in First-Episode Psychosis', Healthcare, vol. 10. https://doi.org/10.3390/healthcare10112155

TY - JOUR

T1 - Heterogeneity in Response to MCT and Psychoeducation :

T2 - A Feasibility Study Using Latent Class Mixed Models in First-Episode Psychosis

AU - Ferrer-Quintero, Marta

AU - Fernández, Daniel

AU - López-Carrilero, Raquel

AU - Díaz-Cutraro, L

AU - Verdaguer-Rodríguez, Marina

AU - García-Mieres, Helena

AU - Huerta-Ramos, Elena

AU - Gómez-Benito, Juana

AU - Peláez, Trini

AU - Birulés, Irene

AU - Barajas Vélez, Ana

AU - Pousa, Esther

AU - Barrigón, María Luisa

AU - Gutiérrez-Zotes, Alfonso

AU - Grasa, Eva

AU - Ruiz-Delgado, Isabel

AU - Lorente-Rovira, Esther

AU - Cid Colom, Jordi

AU - Ochoa, Susana

PY - 2022

Y1 - 2022

N2 - Metacognitive training (MCT) is an effective treatment for psychosis. Longitudinal trajectories of treatment response are unknown but could point to strategies to maximize treatment efficacy during the first episodes. This work aims to explore the possible benefit of using latent class mixed models (LCMMs) to understand how treatment response differs between metacognitive training and psychoeducation. We conducted LCMMs in 28 patients that received MCT and 34 patients that received psychoeducation. We found that MCT is effective in improving cognitive insight in all patients but that these effects wane at follow-up. In contrast, psychoeducation does not improve cognitive insight, and may increase self-certainty in a group of patients. These results suggest that LCMMs are valuable tools that can aid in treatment prescription and in predicting response to specific treatments.

AB - Metacognitive training (MCT) is an effective treatment for psychosis. Longitudinal trajectories of treatment response are unknown but could point to strategies to maximize treatment efficacy during the first episodes. This work aims to explore the possible benefit of using latent class mixed models (LCMMs) to understand how treatment response differs between metacognitive training and psychoeducation. We conducted LCMMs in 28 patients that received MCT and 34 patients that received psychoeducation. We found that MCT is effective in improving cognitive insight in all patients but that these effects wane at follow-up. In contrast, psychoeducation does not improve cognitive insight, and may increase self-certainty in a group of patients. These results suggest that LCMMs are valuable tools that can aid in treatment prescription and in predicting response to specific treatments.

KW - First-episode psychosis

KW - Social cognition

KW - Metacognition

KW - Latent class mixed models

KW - Metacognitive training

KW - Psychoeducation

UR - https://www.scopus.com/pages/publications/85141748571

U2 - 10.3390/healthcare10112155

DO - 10.3390/healthcare10112155

M3 - Article

C2 - 36360496

SN - 2227-9032

VL - 10

JO - Healthcare

JF - Healthcare

ER -

Heterogeneity in Response to MCT and Psychoeducation : A Feasibility Study Using Latent Class Mixed Models in First-Episode Psychosis

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Keywords

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