Hepatosplenic γδ T-cell lymphoma (HSγδTCL) is an uncommon type of peripheral T-cell lymphoma, which has been associated in some cases with immunosuppression, mainly after solid organ transplants. We describe a case of HSγδTCL with a leukaemic course in a patient with Crohn's disease who had received azathioprine during the previous 55 years. Sinusoidal infiltration by atypical lymphocytes was observed in the liver, spleen and bone marrow and the typical cytogenetic abnormalities (isochromosome 7 and trisomy 8) were found. The patient did not respond to intensive chemotherapy. This case shows the importance of ruling out HSγδTCL in patients with hepatosplenomegaly, B-symptoms and any immunosuppressive condition.
- Crohn's disease
- Gammadelta T-cell lymphoma