Hepatosplenic T-gammadelta lymphoma in a patient with Crohn's disease treated with azathioprine

José Tomás Navarro, Josep Maria Ribera, José Luis Mate, Isabel Granada, Jordi Juncà, Montserrat Batlle, Fuensanta Millá, Evarist Feliu

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78 Citations (Scopus)

Abstract

Hepatosplenic γδ T-cell lymphoma (HSγδTCL) is an uncommon type of peripheral T-cell lymphoma, which has been associated in some cases with immunosuppression, mainly after solid organ transplants. We describe a case of HSγδTCL with a leukaemic course in a patient with Crohn's disease who had received azathioprine during the previous 55 years. Sinusoidal infiltration by atypical lymphocytes was observed in the liver, spleen and bone marrow and the typical cytogenetic abnormalities (isochromosome 7 and trisomy 8) were found. The patient did not respond to intensive chemotherapy. This case shows the importance of ruling out HSγδTCL in patients with hepatosplenomegaly, B-symptoms and any immunosuppressive condition.
Original languageEnglish
Pages (from-to)531-533
JournalLeukemia and Lymphoma
Volume44
Issue number3
DOIs
Publication statusPublished - 1 Mar 2003

Keywords

  • Azathioprine
  • Crohn's disease
  • Gammadelta T-cell lymphoma
  • Hepatosplenomegaly

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