Hepatitis in exanthematous Mediterranean fever

J. Guardia; J. Vilaseca; A. Moragas; J. M. Martinez-Vazquez; J. A. Bombi; J. Calders; R. Bacardi

Hepatitis in exanthematous Mediterranean fever

J. Guardia, J. Vilaseca, A. Moragas, J. M. Martinez-Vazquez, J. A. Bombi, J. Calders, R. Bacardi

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

13 Citations (Scopus)

Abstract

In 38 patients suffering from rickettsiosis caused by Rickettsia conorii (Mediterranean Exanthematous Fever), hepatic involvement was studied via laboratory tests and in 26 cases by means of liver biopsy. SGOT, SGPT and alkaline phosphatase were found to be elevated in more than half of the patients (SGOT 74.4 ± 93 U.K., SGPT 82.2 ± 93 U.K., a.p. 58 ± 21 mU/ml). In 14 patients, liver biopsy showed the existence of inclusion corpuscles in Kupffer's cells. Electron microscopic study demonstrated the existence of phagosomes inside the epithelioid cells, which, however, were difficult to categorize. The frequent existence of granulomatous hepatitis in this rickettsiosis was confirmed, while the presence of the infecting agent in the liver could not be established.

Original language	English
Pages (from-to)	81-83
Journal	Hepato-Gastroenterology
Volume	28
Issue number	2
Publication status	Published - 20 Jul 1981

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title = "Hepatitis in exanthematous Mediterranean fever",

abstract = "In 38 patients suffering from rickettsiosis caused by Rickettsia conorii (Mediterranean Exanthematous Fever), hepatic involvement was studied via laboratory tests and in 26 cases by means of liver biopsy. SGOT, SGPT and alkaline phosphatase were found to be elevated in more than half of the patients (SGOT 74.4 ± 93 U.K., SGPT 82.2 ± 93 U.K., a.p. 58 ± 21 mU/ml). In 14 patients, liver biopsy showed the existence of inclusion corpuscles in Kupffer's cells. Electron microscopic study demonstrated the existence of phagosomes inside the epithelioid cells, which, however, were difficult to categorize. The frequent existence of granulomatous hepatitis in this rickettsiosis was confirmed, while the presence of the infecting agent in the liver could not be established.",

author = "J. Guardia and J. Vilaseca and A. Moragas and Martinez-Vazquez, {J. M.} and Bombi, {J. A.} and J. Calders and R. Bacardi",

year = "1981",

month = jul,

day = "20",

language = "English",

volume = "28",

pages = "81--83",

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TY - JOUR

T1 - Hepatitis in exanthematous Mediterranean fever

AU - Guardia, J.

AU - Vilaseca, J.

AU - Moragas, A.

AU - Martinez-Vazquez, J. M.

AU - Bombi, J. A.

AU - Calders, J.

AU - Bacardi, R.

PY - 1981/7/20

Y1 - 1981/7/20

N2 - In 38 patients suffering from rickettsiosis caused by Rickettsia conorii (Mediterranean Exanthematous Fever), hepatic involvement was studied via laboratory tests and in 26 cases by means of liver biopsy. SGOT, SGPT and alkaline phosphatase were found to be elevated in more than half of the patients (SGOT 74.4 ± 93 U.K., SGPT 82.2 ± 93 U.K., a.p. 58 ± 21 mU/ml). In 14 patients, liver biopsy showed the existence of inclusion corpuscles in Kupffer's cells. Electron microscopic study demonstrated the existence of phagosomes inside the epithelioid cells, which, however, were difficult to categorize. The frequent existence of granulomatous hepatitis in this rickettsiosis was confirmed, while the presence of the infecting agent in the liver could not be established.

AB - In 38 patients suffering from rickettsiosis caused by Rickettsia conorii (Mediterranean Exanthematous Fever), hepatic involvement was studied via laboratory tests and in 26 cases by means of liver biopsy. SGOT, SGPT and alkaline phosphatase were found to be elevated in more than half of the patients (SGOT 74.4 ± 93 U.K., SGPT 82.2 ± 93 U.K., a.p. 58 ± 21 mU/ml). In 14 patients, liver biopsy showed the existence of inclusion corpuscles in Kupffer's cells. Electron microscopic study demonstrated the existence of phagosomes inside the epithelioid cells, which, however, were difficult to categorize. The frequent existence of granulomatous hepatitis in this rickettsiosis was confirmed, while the presence of the infecting agent in the liver could not be established.

M3 - Article

SN - 0172-6390

VL - 28

SP - 81

EP - 83

JO - Acta hepato-splenologica

JF - Acta hepato-splenologica

IS - 2

ER -

Hepatitis in exanthematous Mediterranean fever

Abstract

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