Height gain at adult-height age in 184 short patients treated with growth hormone from prepubertal age to near adult-height age is not related to GH secretory status at GH therapy onset

A. Carrascosa, L. Audí, M. Fernández-Cancio, D. Yeste, M. Gussinye, A. Campos, M. A. Albisu, M. Clemente, J. Bel, R. Nosás, M. Rabanal, C. Del Pozo, J. M. Gómez, J. Mesa

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

Background: GH release after stimuli classifies short children as severe idiopathic isolated GH deficiency (IIGHD), mild IIGHD, dissociated GH release (DGHR) and normal GH release (NGHR) and anthropometric birth data as adequate for gestational age (AGA) or small for gestational age (SGA). GH release after stimuli classifies AGA patients as IIGHD or as idiopathic short stature (ISS). Aim: To compare height gain induced by GH therapy (31.8 ± 3.5 μg/kg/day, 7.7 ± 1.6 years) started at prepubertal age and stopped at near adult-height age. Methods: A retrospective longitudinal multicenter study including 184 short patients classified as severe IIGHD n = 25, mild IIGHD n = 75, DGHR n = 55 and NGHR n = 29; or as IIGHD n = 78, ISS n = 57 and SGA n = 49. Height gain was evaluated throughout GH therapy and at adult-height age. Results: Height-SDS gain at adult-height age was similar among severe IIGHD (1.8 ± 0.8 SDS), mild IIGHD (1.6 ± 0.6 SDS), DGHR (1.7 ± 0.7 SDS) and NGHR (1.6 ± 0.7 SDS), or among IIGHD (1.7 ± 0.7 SDS), ISS (1.7 ± 0.6 SDS) and SGA (1.6 ± 0.8 SD). Conclusion: GH-release stimuli are of little help for deciding on GH therapy in the clinical management of prepubertal children with IIGHD, ISS or SGA. Copyright © 2013 S. Karger AG, Basel.
Original languageEnglish
Pages (from-to)145-156
JournalHormone Research in Paediatrics
Volume79
Issue number3
DOIs
Publication statusPublished - 1 Apr 2013

Keywords

  • GH therapy
  • GH-release secretory stimuli
  • Idiopathic isolated GH deficiency
  • Idiopathic short stature
  • Small for gestational age

Fingerprint Dive into the research topics of 'Height gain at adult-height age in 184 short patients treated with growth hormone from prepubertal age to near adult-height age is not related to GH secretory status at GH therapy onset'. Together they form a unique fingerprint.

Cite this