Health-related quality of life in primary and secondary adrenal insufficiency

Anna Aulinas, Susan M. Webb

Research output: Contribution to journalReview articleResearchpeer-review

24 Citations (Scopus)


© 2014 Informa UK Ltd. Adrenal insufficiency (AI) is characterized by a deficient production of glucocorticoids with or without associated mineralcorticoid and/or adrenal androgen deficiencies. Despite the low prevalence of AI, its impact on the affected patient is very high, and can be life-threatening disease if not adequately treated. Several glucocorticoid treatment regimens are available, but none is capable of perfectly imitating the cortisol circadian rhythm. Cortisol rhythmicity and treatment of other possible concomitant conditions often associated (e.g., autoimmune disorders and panhypopituitarism) are essential to improve outcome of AI. Morbidity often present in treated AI include an unhealthy metabolic profile, bad quality of sleep, infertility, sexual dysfunction and worse health-related quality of life. This review focuses on psychological morbidity and impaired quality of life in patients with primary or secondary AI of any origin, including a special section devoted to congenital adrenal hyperplasia.
Original languageEnglish
Pages (from-to)873-888
JournalExpert Review of Pharmacoeconomics and Outcomes Research
Issue number6
Publication statusPublished - 1 Jan 2014


  • Addison's disease
  • Congenital adrenal hyperplasia
  • Health-related quality of life
  • Primary adrenal insufficiency
  • Quality of life
  • Secondary adrenal insufficiency


Dive into the research topics of 'Health-related quality of life in primary and secondary adrenal insufficiency'. Together they form a unique fingerprint.

Cite this