Health-related quality of life associated with different symptoms in women and in men who suffer from schizophrenia

Cristina Domenech, Corrado Bernasconi, Maria Victoria Moneta, Anna Lena Nordstroem, Paula Cristobal-Narvaez, Ellen Vorstenbosch, Jesus Cobo, Susana Ochoa, Josep Maria Haro

Research output: Contribution to journalArticleResearch

Abstract

© 2018, Springer-Verlag GmbH Austria, part of Springer Nature. Health-related quality of life (HRQoL) in patients with schizophrenia is related to the severity of psychiatric symptoms. The objective of this study is to analyze whether the symptoms that influence HRQoL are similar in women and men. Data were part of the Pattern study, an international observational investigation which collected data from 1379 outpatients with schizophrenia. Patients were evaluated with the Mini International Neuropsychiatric Inventory, the Clinical Global Impression-Schizophrenia, and the Positive and Negative Syndrome Scale (PANSS), and reported their quality of life using the Schizophrenia Quality of Life Scale (SQLS), the Short Form-36 (SF-36), and the EuroQol-5 Dimension (EQ-5D). Men reported higher HRQoL on all scales. PANSS total score was 80.6 (SD 23.6) for women and 77.9 (SD 22.1) for men. In women, a higher PANSS negative score and a higher PANSS affective score were associated with a lower SQLS score. In men, a higher PANSS positive score and a higher PANSS affective score were associated with a lower SQLS score. The same pattern appeared with EQ-VAS and EQ-5D tariff. In women, greater age and higher PANSS affective score were associated with a lower SF-36 mental component score. In men, higher PANSS affective, positive, and cognitive scores were associated with a lower SF-36 mental component score. This study shows that HRQoL is influenced by different psychiatric symptoms in women and men. This may have significant implications when deciding the main treatment target in patients with schizophrenia. ClinicalTrials.gov Identifier: https://clinicaltrials.gov/ct2/show/NCT01634542.
Original languageEnglish
Pages (from-to)357-365
JournalArchives of Women's Mental Health
Volume22
DOIs
Publication statusPublished - 1 Jun 2019

Keywords

  • Gender
  • Health-related quality of life
  • Negative symptoms
  • Positive symptoms
  • Schizophrenia

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