Head and voice tremor improving with immunotherapy in an anti-NF155 positive CIDP patient

Cèlia Painous, Mª Ángeles López-Pérez, Isabel Illa, Luis Querol

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

© 2018 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. Chronic inflammatory demyelinating polyradiculoneuropathy with NF155 antibodies (anti-NF155+) constitutes a specific chronic inflammatory demyelinating polyradiculoneuropathy subset with a high incidence of limb's tremor and poor response to conventional therapies. We report a patient with chronic inflammatory demyelinating polyradiculoneuropathy anti-NF155+ with a severe tremor involving limbs, head and voice that responded very well to rituximab. This response correlated with a sharp decrease in the anti-NF155 titers. This case is the first report associating head and voice tremor to chronic inflammatory demyelinating polyradiculoneuropathy, reinforces the hypothesis of the cerebellar origin of this tremor and provides indirect evidence that the antibodies may be the cause of the tremor in these patients.
Original languageEnglish
Pages (from-to)499-501
JournalAnnals of Clinical and Translational Neurology
Volume5
Issue number4
DOIs
Publication statusPublished - 1 Apr 2018

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