HDV evolution—will viral resistance be an issue in HDV infection?

David Tabernero, Maria Francesca Cortese, Maria Buti, Francisco Rodriguez-Frias

    Research output: Contribution to journalReview articleResearchpeer-review

    Abstract

    © 2018 Elsevier B.V. Hepatitis D virus (HDV) is a hepatotropic subviral infectious agent, obligate satellite of the Hepatitis B virus (HBV) and is highly related to viroids. HDV affects around 5% of the 257 million chronic HBV-carriers worldwide, leading to the most severe form of chronic viral hepatitis. Interferon alpha is the only approved treatment for chronic hepatitis D, albeit with low response rates (around 20%–30%). New antiviral strategies are currently under study. Due to the high viral evolution rates (10−3 to 10−4 substitutions/site/year) HDV forms an extremely complex viral population (quasispecies) that can be studied by Next-Generation Sequencing. Therefore, although specific viral resistance in HDV infection has not been reported, it cannot be completely discarded.
    Original languageEnglish
    Pages (from-to)100-107
    JournalCurrent Opinion in Virology
    Volume32
    DOIs
    Publication statusPublished - 1 Oct 2018

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