Since some surface-antigen (HBsAg) negative hepatitis show positive core-antigen antibodies (anti-HBc), the possibility is raised that they be due to type B hepatitis virus. Furthermore, it has been shown that hepatitis can be transmitted by HBsAg-negative blood with anti-HBc antibodies. Nine cases of post-transfusion hepatitis plus 2 patients transfused with HBsAg-negative, anti-HBc-positive blood, were studied. Five of the post-transfusion hepatitis patients had positive anti-HBc, with a short incubation period (15 to 35 days). No hepatitis appeared in the patients transfused with HBsAg-negative, anti-HBc-positive blood after four months, the determinations for HBsAg and anti-HBc being consistently negative. These findings stress the necessity for studying anti-HBc antibodies before considering as non-B a given case of hepatitis; also they suggest that HBs-negative anti-HBc-positive blood may be non-infective in some instances.
|Publication status||Published - 1 Jan 1979|