Haptoglobin and pig-major acute protein are increased in pigs with postweaning multisystemic wasting syndrome (PMWS)

Joaquim Segalés, Carlos Piñero, Fermín Lampreave, Miquel Nofrarías, Enric Mateu, Maria Calsamiglia, Marta Andrés, Joaquín Morales, Matilde Piñeiro, Mariano Domingo

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38 Citations (Scopus)


The objective of this study was to determine the serum concentration levels of selected acute phase proteins (APP), haptoglobin (HPT) and pig-major acute phase protein (pig-MAP), in postweaning multisystemic wasting syndrome (PMWS) affected pigs and PCV2-subclinically infected pigs. In a first study, a group of 15 eight-week-old conventional pigs from a PMWS affected farm were bled and a complete necropsy, histopathology and in situ hybridisation to detect PCV2 were performed. Based on the results, pigs were classified as suffering from PMWS (n = 10) or healthy animals (n = 5). In a second study, a group of 45 pigs from another PMWS affected farm were selected and bled at 3, 7, 12 and 28 weeks of age. The assessment of PCV2 infection status in these pigs was retrospectively done by PCV2 PCR in serum samples. Selected APP were measured in the serum of all studied pigs by means of radial immunodiffusion. Mean HPT and pig-MAP levels were significantly increased (p = 0.004 and p = 0.0006 respectively) in PMWS-affected pigs when compared to levels found in healthy pigs (2.52 ± 0.88 mg/mL vs. 1.06 ± 0.73 mg/mL for HPT and 3.81 ± 1.53 mg/mL vs. 0.76 ± 0.34 mg/mL for pig-MAP). In the second study, no significant difference in mean HPT and pig-MAP values were observed between PCV2 PCR positive and negative pigs of any age. However, both APP increased significantly with age in PCV2 PCR negative pigs. Altogether, the present results suggest that APP levels are significantly increased in pigs that develop PMWS, but not in animals with a PCV2 subclinical infection. © INRA, EDP Sciences, 2004.
Original languageEnglish
Pages (from-to)275-282
JournalVeterinary Research
Publication statusPublished - 1 May 2004


  • Acute phase proteins
  • Haptoglobin
  • Pig major acute phase protein (pig-MAP)
  • Porcine circovirus type 2 (PCV2)
  • Postweaning multisystemic wasting syndrome(PMWS)


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